MAPK13

This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

Description

Mitogen-activated protein kinase 13

Tissue specificity

Tissue enhanced (esophagus)

Subcell location

Nucleoplasm, Nucleoli, Nucleoli rim, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

6 (36127809 - 36144524)

Ensembl ID

ENSG00000156711  (ver. 103.38)

Orthologs

Mouse Mapk13: ENSMUSG00000004864

UniProt

O15264

neXtProt

NX_O15264

Human splice variants
Mouse splice variants

Protein structure