Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Blocking/Neutralizing [1]
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- Product number
- AF431 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal MSPR/Ron Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Detects mouse MSP R/Ron in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human MSP R/Ron is observed.
- Reactivity
- Mouse
- Host
- Goat
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Neuroprotective Role of the Ron Receptor Tyrosine Kinase Underlying Central Nervous System Inflammation in Health and Disease.
Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.
Dey A, Allen JN, Fraser JW, Snyder LM, Tian Y, Zhang L, Paulson RF, Patterson A, Cantorna MT, Hankey-Giblin PA
Frontiers in immunology 2018;9:513
Frontiers in immunology 2018;9:513
Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.
Kauder SE, Santell L, Mai E, Wright LY, Luis E, N'Diaye EN, Lutman J, Ratti N, Sa SM, Maun HR, Stefanich E, Gonzalez LC, Graham RR, Diehl L, Faubion WA Jr, Keir ME, Young J, Chaudhuri A, Lazarus RA, Egen JG
PloS one 2013;8(12):e83958
PloS one 2013;8(12):e83958
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
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- Experimental details
- Chemotaxis Induced by MSP and Neutralization by Mouse MSP R/Ron Antibody. Recombinant Human MSP (Catalog # 352-MS) chemoattracts mouse peritoneal macrophages in a dose-dependent manner (orange line). The amount of cells that migrated through filter was measured by LeukoStat™ staining (Fisher Scientific) . Chemotaxis elicited by Recombinant Human MSP (50 ng/mL) is neutralized (green line) by increasing concentrations of Mouse MSP R/Ron Antigen Affinity-purified Polyclonal Antibody (Catalog # AF431). The ND50 is typically 0.05-0.2 µg/mL.