LMTK2

The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]

Description

Lemur tyrosine kinase 2

Tissue specificity

Low tissue specificity

Subcell location

Nuclear speckles, Plasma membrane, Centriolar satellite, Cytosol

Predicted location

Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

7 (98106862 - 98209638)

Ensembl ID

ENSG00000164715  (ver. 103.38)

Orthologs

Mouse Lmtk2: ENSMUSG00000038970

UniProt

Q8IWU2

neXtProt

NX_Q8IWU2

Human splice variants
Mouse splice variants

Protein structure