ABIN966486

antibody from antibodies-online

Targeting: LIMK2

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN966486

Provider

antibodies-online

Product name

anti-LIM Domain Kinase 2 (LIMK2) (pThr505) antibody

Antibody type

Polyclonal

Antigen

The antiserum was produced against synthesized phosphopeptide derived from human LIMK2 around the phosphorylation site of threonine 505 (R-Y-TP-V-V).

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Epitope

pThr505

Vial size

100 μg

Concentration

100ug/100ul.

Storage

-20°C

References

Submitted references

Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin.

Soosairajah J, Maiti S, Wiggan O, Sarmiere P, Moussi N, Sarcevic B, Sampath R, Bamburg JR, Bernard O
The EMBO journal 2005 Feb 9;24(3):473-86

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Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop.

Ohashi K, Nagata K, Maekawa M, Ishizaki T, Narumiya S, Mizuno K
The Journal of biological chemistry 2000 Feb 4;275(5):3577-82

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Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics.

Edwards DC, Sanders LC, Bokoch GM, Gill GN
Nature cell biology 1999 Sep;1(5):253-9