Tissue expression
Cell line expression

LIMK2

gene product
 
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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578 antibodies from 37 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Invitrogen Antibodies
28 antibodies
OriGene
17 antibodies
GeneTex
6 antibodies
LifeSpan BioSciences, Inc.
59 antibodies
Novus Biologicals
6 antibodies
antibodies-online
208 antibodies
Aviva Systems Biology
8 antibodies
Biorbyt
44 antibodies
Atlas Antibodies
1 antibody
Cusabio Biotech Co., Ltd
10 antibodies
Affinity Biosciences
6 antibodies
Acris Antibodies GmbH
10 antibodies
Abnova Corporation
9 antibodies
Proteintech Group
1 antibody
Signalway Antibody LLC
3 antibodies
Boster Biological Technology
4 antibodies
Bioworld Technology, Inc
4 antibodies
NovoPro Bioscience Inc.
5 antibodies
Abgent
5 antibodies
ProSci
2 antibodies
Enzo Life Sciences
4 antibodies
RabMAbs
3 antibodies
Abbkine Scientific Co.Ltd.
5 antibodies
Antibodies.com
1 antibody
Cell Signaling Technology, Inc
1 antibody
Wuhan Fine Biotech Co., Ltd.
1 antibody
NSJ Bioreagents
2 antibodies
Abbexa
15 antibodies
MilliporeSigma / Merck KGaA
6 antibodies
Creative Biolabs
11 antibodies
Arigo
2 antibodies
United States Biological
75 antibodies
MyBioSource
5 antibodies
Creative Diagnostics
5 antibodies
Leading Biology
3 antibodies
GenWay
2 antibodies
RayBiotech, Inc.
1 antibody