ADRA2C

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]

Description

Adrenoceptor alpha 2C

Tissue specificity

Tissue enhanced (cervix, endometrium)

Predicted location

Membrane

Protein family

FDA approved drug targets
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

4 (3766348 - 3768526)

Ensembl ID

ENSG00000184160  (ver. 103.38)

Orthologs

Mouse Adra2c: ENSMUSG00000045318

UniProt

P18825

neXtProt

NX_P18825

Human splice variants
Mouse splice variants

Protein structure