MAB6942

antibody from R&D Systems

Targeting: TNFSF18 AITRL, hGITRL, TL6

ELISA (Recommended by provider)

Flow cytometry (Recommended by provider)

Blocking/Neutralizing (Recommended by provider)

Antibody Data

Product number

MAB6942

Provider

R&D Systems

Product name

Anti-Human GITR Ligand/TNFSF18 Monoclonal Antibody (Clone 109114)

Antibody type

Monoclonal

Antigen

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human GITR Ligand/TNFSF18, Glu52-Ser177

Description

Protein A or G purified from hybridoma culture supernatant

Reactivity

Human

Host

Mouse

Antigen sequence

Q9UNG2


Isotype

IgG

Vial size

500 µg

References

Submitted references

Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells.

Tuyaerts S, Van Meirvenne S, Bonehill A, Heirman C, Corthals J, Waldmann H, Breckpot K, Thielemans K, Aerts JL
Journal of leukocyte biology 2007 Jul;82(1):93-105

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Cancer immunoediting by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell interactions.

Baltz KM, Krusch M, Bringmann A, Brossart P, Mayer F, Kloss M, Baessler T, Kumbier I, Peterfi A, Kupka S, Kroeber S, Menzel D, Radsak MP, Rammensee HG, Salih HR
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007 Aug;21(10):2442-54

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Glucocorticoid-induced tumour necrosis factor receptor (GITR) and its ligand (GITRL) in atopic dermatitis.

Baumgartner-Nielsen J, Vestergaard C, Thestrup-Pedersen K, Deleuran M, Deleuran B
Acta dermato-venereologica 2006;86(5):393-8

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Expression of GITR ligand abrogates immunosuppressive function of ocular tissue and differentially modulates inflammatory cytokines and chemokines.

Mahesh SP, Li Z, Liu B, Fariss RN, Nussenblatt RB
European journal of immunology 2006 Aug;36(8):2128-38