ARHGAP24

This gene encodes a Rho-GTPase activating protein, which is specific for the small GTPase family member Rac. Binding of the encoded protein by filamin A targets it to sites of membrane protrusion, where it antognizes Rac. This results in suppression of lamellae formation and promotion of retraction to regulate cell polarity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Description

Rho GTPase activating protein 24

Tissue specificity

Tissue enhanced (kidney)

Subcell location

Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (85475150 - 86002668)

Ensembl ID

ENSG00000138639  (ver. 103.38)

Orthologs

Mouse Arhgap24: ENSMUSG00000057315

UniProt

Q8N264

neXtProt

NX_Q8N264

Human splice variants
Mouse splice variants