Antibody data
- Antibody Data
- Antigen structure
- References [7]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- FAB1844P-025 - Provider product page
- Provider
- R&D Systems
- Product name
- Human KIR2DL1/KIR2DS5 PE-conjugated Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human KIR2DL1/KIR2DS5 on transfected cells. It does not stain cells transfected with KIR2DL2, 2DL3, 2DL4, 2DL5, 2DS1, 2DS2, 2DS4, 3DL1, 3DL2, or 3DS1.
- Reactivity
- Human
- Host
- Mouse
- Antigen sequence
P43626
- Isotype
- IgG
- Antibody clone number
- 143211
- Vial size
- 25 Tests
- Storage
- Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.
Submitted references Human NK cell receptor KIR2DS4 detects a conserved bacterial epitope presented by HLA-C.
Contribution of NK Cell Education to both Direct and Anti-HIV-1 Antibody-Dependent NK Cell Functions.
Modulation of the natural killer cell KIR repertoire by cytomegalovirus infection.
Natural killer lysis receptor (NKLR)/NKLR-ligand matching as a novel approach for enhancing anti-tumor activity of allogeneic NK cells.
Blocking NK cell inhibitory self-recognition promotes antibody-dependent cellular cytotoxicity in a model of anti-lymphoma therapy.
Functional impairment in circulating and intrahepatic NK cells and relative mechanism in hepatocellular carcinoma patients.
Natural killer cells in perinatally HIV-1-infected children exhibit less degranulation compared to HIV-1-exposed uninfected children and their expression of KIR2DL3, NKG2C, and NKp46 correlates with disease severity.
Sim MJW, Rajagopalan S, Altmann DM, Boyton RJ, Sun PD, Long EO
Proceedings of the National Academy of Sciences of the United States of America 2019 Jun 25;116(26):12964-12973
Proceedings of the National Academy of Sciences of the United States of America 2019 Jun 25;116(26):12964-12973
Contribution of NK Cell Education to both Direct and Anti-HIV-1 Antibody-Dependent NK Cell Functions.
Kristensen AB, Kent SJ, Parsons MS
Journal of virology 2018 Jun 1;92(11)
Journal of virology 2018 Jun 1;92(11)
Modulation of the natural killer cell KIR repertoire by cytomegalovirus infection.
Charoudeh HN, Terszowski G, Czaja K, Gonzalez A, Schmitter K, Stern M
European journal of immunology 2013 Feb;43(2):480-7
European journal of immunology 2013 Feb;43(2):480-7
Natural killer lysis receptor (NKLR)/NKLR-ligand matching as a novel approach for enhancing anti-tumor activity of allogeneic NK cells.
Markel G, Seidman R, Besser MJ, Zabari N, Ortenberg R, Shapira R, Treves AJ, Loewenthal R, Orenstein A, Nagler A, Schachter J
PloS one 2009;4(5):e5597
PloS one 2009;4(5):e5597
Blocking NK cell inhibitory self-recognition promotes antibody-dependent cellular cytotoxicity in a model of anti-lymphoma therapy.
Binyamin L, Alpaugh RK, Hughes TL, Lutz CT, Campbell KS, Weiner LM
Journal of immunology (Baltimore, Md. : 1950) 2008 May 1;180(9):6392-401
Journal of immunology (Baltimore, Md. : 1950) 2008 May 1;180(9):6392-401
Functional impairment in circulating and intrahepatic NK cells and relative mechanism in hepatocellular carcinoma patients.
Cai L, Zhang Z, Zhou L, Wang H, Fu J, Zhang S, Shi M, Zhang H, Yang Y, Wu H, Tien P, Wang FS
Clinical immunology (Orlando, Fla.) 2008 Dec;129(3):428-37
Clinical immunology (Orlando, Fla.) 2008 Dec;129(3):428-37
Natural killer cells in perinatally HIV-1-infected children exhibit less degranulation compared to HIV-1-exposed uninfected children and their expression of KIR2DL3, NKG2C, and NKp46 correlates with disease severity.
Ballan WM, Vu BA, Long BR, Loo CP, Michaƫlsson J, Barbour JD, Lanier LL, Wiznia AA, Abadi J, Fennelly GJ, Rosenberg MG, Nixon DF
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 1;179(5):3362-70
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 1;179(5):3362-70
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of KIR2DL1/KIR2DS5 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human KIR2DL1/KIR2DS5 PE-conjugated Monoclonal Antibody (Catalog # FAB1844P) and Mouse Anti-Human NCAM-1/CD56 APC-conjugated Monoclonal Antibody (Catalog # FAB2408A). Quadrant marker was set based on isotype control antibody staining (Catalog # IC002P). View our protocol for Staining Membrane-associated Proteins.