KIR2DL1

gene product
47.11, CD158A, cl-42, nkat1, p58.1
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several ""framework"" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
652 antibodies from 27 providers.

Antibody properties

General

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
239 antibodies
Novus Biologicals
108 antibodies
R&D Systems
28 antibodies
GeneTex
6 antibodies
Biorbyt
25 antibodies
Affinity Biosciences
1 antibody
Invitrogen Antibodies
10 antibodies
Abnova Corporation
5 antibodies
Aviva Systems Biology
2 antibodies
Bioworld Technology, Inc
1 antibody
Acris Antibodies GmbH
4 antibodies
LifeSpan BioSciences, Inc.
57 antibodies
Boster Biological Technology
2 antibodies
Antibodies.com
1 antibody
BioLegend
7 antibodies
OriGene
4 antibodies
Creative Biolabs
30 antibodies
GenWay
10 antibodies
MyBioSource
6 antibodies
Creative Diagnostics
11 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Miltenyi Biotec
41 antibodies
St John's Laboratory
2 antibodies
United States Biological
24 antibodies
Abbexa
1 antibody
Sigma-Aldrich
1 antibody