Tissue expression
Cell line expression
Protein structure
UVRAG
UV radiation resistance associatedVPS38
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Novus Biologicals | 2 references | Polyclonal |
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| antibodies-online | 1 references | Polyclonal |
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| Proteintech Group | 4 references | Polyclonal |
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| GeneTex | Polyclonal |
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| Invitrogen Antibodies | Polyclonal |
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