UVRAG

This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]

Description

UV radiation resistance associated

Protein family

Disease related genes, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

11:q13.5 (75815167 - 76143195)

Ensembl ID

ENSG00000198382  (ver. 84.38)

Orthologs

Mouse Uvrag: ENSMUSG00000035354

UniProt

Q9P2Y5

neXtProt

NX_Q9P2Y5

Human splice variants
Mouse splice variants