22515-1-AP

antibody from Proteintech Group

Targeting: SLC1A2 EAAT2, GLT-1

Provider product page for 22515-1-AP

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Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [34]
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Validations
Immunohistochemistry [1]

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Product number: 22515-1-AP - Provider product page
Provider: Proteintech Group
Product name: EAAT2 antibody
Antibody type: Polyclonal
Description: EAAT2 antibody (Cat. #22515-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SLC1A2 protein structure - 22515-1-AP shown in red.

Submitted references Tuina Inhibits Synaptic Plasticity Through the Astrocytic NDRG2/GLT-1 Pathway to Alleviate Neuropathic Pain.

Zhang H, Chen L, Jiang J, Huang L, Huang H, Huang L, Chen S, Lin Z
Journal of cellular and molecular medicine 2026 Jan;30(1):e71013

SA supplementation during lactation promotes learning and memory by reducing H3K27me3 levels.

Huang C, Ai S, Wang M, Li C, Wang K, Nie M, Zhang H, Gu X, Wang HL
Journal of advanced research 2026 Feb;80:301-316

Remote Regulation of Molecular Diffusion in Extracellular Space of Parkinson's Disease Rat Model by Subthalamic Nucleus Deep Brain Stimulation.

Du D, Fu W, Su S, Mao X, Yang L, Xu M, Yuan Y, Gao Y, Geng Z, Chen Y, Zhao M, Fu Y, Yin F, Han H
Cyborg and bionic systems (Washington, D.C.) 2025;6:0218

An unrecognized mechanism of self-protection in degenerating neurons mediated by astrocytic YAP through Wnts/β-catenin/EAAT2 signaling in C9orf72-poly-GA mice.

Li D, Wei Y, Yang R, Luo X, Liu Y, Zhao W, Yang H, Wu Y, Wang Y, Huang Z
Theranostics 2025;15(16):8176-8201

Inhibition of spreading depolarizations by targeting GABA(A) receptors and voltage-gated sodium channels improves neurological deficits in rats with traumatic brain injury.

Yan R, Liu Q, Zhang D, Li K, Li Y, Nie Y, Zhang Y, Li P, Mao S, Li H
British journal of pharmacology 2025 Nov;182(21):5247-5268

Astrocytic modulation of GABA transmission in the VTA limits progression of anxiety- and depression-like behaviors in adult mice.

Du J, Diao H, Xu Y, Li X, Yuan C, Nie L, Zhang H, Li J, Wang Y
Cell reports 2025 Jun 24;44(6):115824

Incorporation of graphene oxide into collagenous biomaterials attenuates scar-forming phenotype transition of reactive astrocytes in vitro.

Verstappen K, Klymov A, Marques PAAP, Leeuwenburgh SCG, Walboomers XF
Brain research bulletin 2025 Jul;227:111380

Astroglial membrane camouflaged Ptbp1 siRNA delivery hinders glutamate homeostasis via SDH/Nrf2 pathway.

Liu Y, Ren J, Zhang W, Ding L, Ma R, Zhang M, Zheng S, Liang R, Zhang Y
Biomaterials 2025 Jan;312:122707

Hypoxia-Regulated CD44 and xCT Expression Contributes to Late Postoperative Epilepsy in Glioblastoma.

Kusakabe K, Inoue A, Ohnishi T, Nakamura Y, Ohtsuka Y, Nishikawa M, Yano H, Choudhury ME, Murata M, Matsumoto S, Suehiro S, Yamashita D, Shigekawa S, Watanabe H, Kunieda T
Biomedicines 2025 Feb 5;13(2)

Hyperbaric oxygen ameliorates neuroinflammation in heat-stressed BV-2 microglial cells: potential involvement of EAAT2 regulation.

Zhang ZQ, Zheng XX, He YX, Huang F, Xu AC, Yu XC, He GX
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2025 Dec;42(1):2583133

Tissue zinc restoration alleviates the levodopa-induced dyskinesia via impeding ERK phosphorylation.

Zhang MD, Gu MJ, Wang Q, Zhang SM, Zhou WX, Liu SB, Liu RP, Huang CP, Zhu JH, Wu HM
European journal of nutrition 2025 Apr 18;64(4):159

Dexamethasone alleviates etomidate-induced myoclonus by reversing the inhibition of excitatory amino acid transporters.

Feng Y, Zhang M, Jia SY, Guo YX, Jia X
Frontiers in neuroscience 2024;18:1399653

The m6A reader YTHDC2 promotes the pathophysiology of temporal lobe epilepsy by modulating SLC7A11-dependent glutamate dysregulation in astrocytes.

Zhang K, Yang Z, Yang Z, Du L, Zhou Y, Fu S, Wang X, Li X, Liu D, He X
Theranostics 2024;14(14):5551-5570

Astrocytic neuroligin 3 regulates social memory and synaptic plasticity through adenosine signaling in male mice.

Dang R, Liu A, Zhou Y, Li X, Wu M, Cao K, Meng Y, Zhang H, Gan G, Xie W, Jia Z
Nature communications 2024 Oct 5;15(1):8639

PFOS Elicits Cytotoxicity in Neuron Through Astrocyte-Derived CaMKII-DLG1 Signaling In Vitro Rat Hippocampal Model.

Yang J, Wang Y, Xia Y, Ren Y, Wang Z, Meng X, Li S, Liu X, Shao J
Neurochemical research 2024 May;49(5):1226-1238

High-frequency repetitive transcranial magnetic stimulation improves depressive-like behaviors in CUMS-induced rats by modulating astrocyte GLT-1 to reduce glutamate toxicity.

Wang X, Zhang F, Niu L, Yan J, Liu H, Wang D, Hui J, Dai H, Song J, Zhang Z
Journal of affective disorders 2024 Mar 1;348:265-274

Neuronal small extracellular vesicles carrying miR-181c-5p contribute to the pathogenesis of epilepsy by regulating the protein kinase C-δ/glutamate transporter-1 axis in astrocytes.

Ma L, Wu Q, You Y, Zhang P, Tan D, Liang M, Huang Y, Gao Y, Ban Y, Chen Y, Yuan J
Glia 2024 Jun;72(6):1082-1095

Regulatory roles of histamine receptor in astrocytic glutamate clearance under conditions of increased glucose variability.

Zhou Y, Xie W, Kong C, Luo W, Wei H, Zheng J
Biochemical pharmacology 2024 Dec;230(Pt 3):116611

KYNA Ameliorates Glutamate Toxicity of HAND by Enhancing Glutamate Uptake in A2 Astrocytes.

Chen J, Zou J, Huang P, Gao X, Lun J, Li Y, Gong Z, Cao H
International journal of molecular sciences 2024 Apr 12;25(8)

Astrocyte-neuron communication mediated by the Notch signaling pathway: focusing on glutamate transport and synaptic plasticity.

Li KX, Lu M, Cui MX, Wang XM, Zheng Y
Neural regeneration research 2023 Oct;18(10):2285-2290

ONO-2506 Can Delay Levodopa-induced Dyskinesia in the Early Stage.

Yuan Y, Zhang X, Wu Y, Lian P, Cao X, Xu Y
Neuroscience 2023 Jul 15;523:61-79

Repeated sevoflurane exposures inhibit neurogenesis by inducing the upregulation of glutamate transporter 1 in astrocytes.

Kong F, Zhang Y, Wang T, Zhong L, Feng C, Wu Y
The European journal of neuroscience 2023 Jan;57(2):217-232

Cyanidin Chloride Improves LPS-Induced Depression-Like Behavior in Mice by Ameliorating Hippocampal Inflammation and Excitotoxicity.

Qu D, Ye Z, Zhang W, Dai B, Chen G, Wang L, Shao X, Xiang A, Lu Z, Shi J
ACS chemical neuroscience 2022 Nov 2;13(21):3023-3033

Pharmacological induction of AMFR increases functional EAAT2 oligomer levels and reduces epileptic seizures in mice.

Sha L, Li G, Zhang X, Lin Y, Qiu Y, Deng Y, Zhu W, Xu Q
JCI insight 2022 Aug 8;7(15)

Neuroprotective Effect of Ceftriaxone on MPTP-Induced Parkinson's Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota.

Zhou X, Lu J, Wei K, Wei J, Tian P, Yue M, Wang Y, Hong D, Li F, Wang B, Chen T, Fang X
Oxidative medicine and cellular longevity 2021;2021:9424582

Photobiomodulation Therapy Ameliorates Glutamatergic Dysfunction in Mice with Chronic Unpredictable Mild Stress-Induced Depression.

Zhang D, Shen Q, Wu X, Xing D
Oxidative medicine and cellular longevity 2021;2021:6678276

Quantitative proteomic analysis of cortex in the depressive-like behavior of rats induced by the simulated complex space environment.

Min R, Chen Z, Wang Y, Deng Z, Zhang Y, Deng Y
Journal of proteomics 2021 Apr 15;237:104144

Hsp90 inhibitor HSP990 in very low dose upregulates EAAT2 and exerts potent antiepileptic activity.

Sha L, Chen T, Deng Y, Du T, Ma K, Zhu W, Shen Y, Xu Q
Theranostics 2020;10(18):8415-8429

RAGE Signaling pathway in hippocampus dentate gyrus involved in GLT-1 decrease induced by chronic unpredictable stress in rats.

Yang F, Wang H, Chen H, Ran D, Tang Q, Weng P, Sun Y, Jiang W
Brain research bulletin 2020 Oct;163:49-56

Functional validation of a human GLUD2 variant in a murine model of Parkinson's disease.

Zhang W, Gong J, Ding L, Zhang Z, Pan X, Chen X, Guo W, Zhang X, Yang X, Peng G, Lin Y, Gao F, Li Y, Zhu X, Xuan A, Wang S, Sun X, Zhang Y, Xu P
Cell death & disease 2020 Oct 22;11(10):897

Aucubin Alleviates Seizures Activity in Li-Pilocarpine-Induced Epileptic Mice: Involvement of Inhibition of Neuroinflammation and Regulation of Neurotransmission.

Chen S, Zeng X, Zong W, Wang X, Chen L, Zhou L, Li C, Huang Q, Huang X, Zeng G, Hu K, Ouyang DS
Neurochemical research 2019 Feb;44(2):472-484

Ginsenoside Rb1 prevents MPTP-induced changes in hippocampal memory via regulation of the α-synuclein/PSD-95 pathway.

Qu S, Meng X, Liu Y, Zhang X, Zhang Y
Aging 2019 Apr 4;11(7):1934-1964

HIV and drug abuse mediate astrocyte senescence in a β-catenin-dependent manner leading to neuronal toxicity.

Yu C, Narasipura SD, Richards MH, Hu XT, Yamamoto B, Al-Harthi L
Aging cell 2017 Oct;16(5):956-965

Baicalin protects neonatal rat brains against hypoxic-ischemic injury by upregulating glutamate transporter 1 via the phosphoinositide 3-kinase/protein kinase B signaling pathway.

Zhou ZQ, Li YL, Ao ZB, Wen ZL, Chen QW, Huang ZG, Xiao B, Yan XH
Neural regeneration research 2017 Oct;12(10):1625-1631

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Submitted by: Proteintech Group (provider)
Main image
Experimental details: The EAAT2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human EAAT2. This antibody recognizes human, mouse, rat antigen. The EAAT2 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
Appendix: 22515-1-AP.pdf

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