Tissue expression
Cell line expression
SLC1A2
gene productEAAT2, GLT-1
This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Improper regulation of this gene is thought to be associated with several neurological disorders. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2017]
- Description
- Solute carrier family 1 member 2
- Tissue specificity
- Group enriched (brain, choroid plexus)
- Predicted location
- Intracellular, Membrane
- Protein family
- Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters
- Chromosome
- 11:p13 (35251205 - 35420063)
- Ensembl ID
- ENSG00000110436 (ver. 103.38)
- Orthologs
- Mouse Slc1a2: ENSMUSG00000005089
- UniProt
- P43004
- neXtProt
- NX_P43004
Human splice variants
Mouse splice variants
Ensembl | UniProt | RefSeq | Entrez |
---|---|---|---|
ENSMUST00000005220 ENSMUSP00000005220 |
P43006.184 P43006 | NP_035523.1 NP_035523 | Slc1a2 20511 |
ENSMUST00000080210 ENSMUSP00000079100 |
P43006.184 P43006 | NP_001070982.1 NP_001070982 | Slc1a2 20511 |
ENSMUST00000111212 ENSMUSP00000106843 |
P43006.184 P43006 | NP_001070983.1 NP_001070983 | Slc1a2 20511 |
ENSMUST00000111213 ENSMUSP00000106844 |
NP_001347947.1 NP_001347947 | Slc1a2 20511 | |
ENSMUST00000123759 ENSMUSP00000115129 |
Slc1a2 20511 | ||
ENSMUST00000136488 ENSMUSP00000122094 |
Slc1a2 20511 | ||
ENSMUST00000154446 ENSMUSP00000117549 |
Slc1a2 20511 |
* nTPM: Normalized TPM levels represent consensus gene expression calculated using two data sets. Read more
RNA data sourced from Human Protein Atlas.