ABIN350137

antibody from antibodies-online

Targeting: CACNA1C CACH2, CACN2, CACNL1A1, Cav1.2, CCHL1A1, LQT8, TS

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN350137

Provider

antibodies-online

Proper citation

Antibodies-Online Cat#ABIN350137, RRID:AB_10781932

Product name

anti-Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C) (AA 50-100) antibody

Antibody type

Polyclonal

Antigen

A synthetic peptide from aa region 50-100 of human CACNA1C conjugated to an immunogenic carrier protein was used as the antigen. The antigen shares 96% identity with mouse, rat and rabbit sequence.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Epitope

AA 50-100

Isotype

IgG

Vial size

500 μg

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Handling

Avoid freeze and thaw cycles.

References

Submitted references

Ca2+ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human alpha1C subunit gene.

Zühlke RD, Bouron A, Soldatov NM, Reuter H
FEBS letters 1998 May 8;427(2):220-4

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Different voltage-dependent inhibition by dihydropyridines of human Ca2+ channel splice variants.

Soldatov NM, Bouron A, Reuter H
The Journal of biological chemistry 1995 May 5;270(18):10540-3

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Cloning, chromosomal localization, and functional expression of the alpha 1 subunit of the L-type voltage-dependent calcium channel from normal human heart.

Schultz D, Mikala G, Yatani A, Engle DB, Iles DE, Segers B, Sinke RJ, Weghuis DO, Klöckner U, Wakamori M
Proceedings of the National Academy of Sciences of the United States of America 1993 Jul 1;90(13):6228-32