Tissue expression
Cell line expression
CACNA1C
gene productCACH2, CACN2, CACNL1A1, Cav1.2, CCHL1A1, LQT8, TS
This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]
- Description
- Calcium voltage-gated channel subunit alpha1 C
- Tissue specificity
- Tissue enhanced (endometrium , heart muscle, intestine)
- Predicted location
- Intracellular, Membrane
- Protein family
- Disease related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters
Voltage-gated ion channels
- Chromosome
- 12:p13.33 (1970786 - 2697950)
- Ensembl ID
- ENSG00000151067 (ver. 103.38)
- Orthologs
- Mouse Cacna1c: ENSMUSG00000051331
- UniProt
- Q13936
- neXtProt
- NX_Q13936
Human splice variants
Mouse splice variants
* nTPM: Normalized TPM levels represent consensus gene expression calculated using two data sets. Read more
RNA data sourced from Human Protein Atlas.