FMO3

gene product
Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide. [provided by RefSeq, Aug 2009]
More gene data

Featured antibodies

Antibodies

 

Filters

Antibodypedia Validation Initiative

Validation method

Application

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
242 antibodies from 28 providers.

Antibody properties

Applications

or Cancel
AntibodyRefsTypeAVIWBELICCIPIHCFC
antibodies-online
62 antibodies
Aviva Systems Biology
4 antibodies
Biorbyt
8 antibodies
GeneTex
3 antibodies
Novus Biologicals
6 antibodies
NovoPro Bioscience Inc.
2 antibodies
Abgent
2 antibodies
Atlas Antibodies
1 antibody
Invitrogen Antibodies
7 antibodies
Affinity Biosciences
1 antibody
LifeSpan BioSciences, Inc.
50 antibodies
Abnova Corporation
4 antibodies
OriGene
10 antibodies
ProSci
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Bioworld Technology, Inc
1 antibody
Boster Biological Technology
3 antibodies
St John's Laboratory
2 antibodies
Acris Antibodies GmbH
3 antibodies
NSJ Bioreagents
2 antibodies
RabMAbs
6 antibodies
MyBioSource
4 antibodies
Creative Diagnostics
4 antibodies
United States Biological
37 antibodies
Sigma-Aldrich
3 antibodies
Creative Biolabs
1 antibody
GenWay
1 antibody