ABIN350022

antibody from antibodies-online

Targeting: KCNA5 HK2, HPCN1, Kv1.5

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN350022

Provider

antibodies-online

Proper citation

Antibodies-Online Cat#ABIN350022, RRID:AB_10783669

Product name

anti-Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1) (Cytoplasmic Loop) antibody

Antibody type

Polyclonal

Antigen

A synthetic peptide from the 3d cytoplasmic loop of human TRPV1 (VR1, capsaicin receptor, vanilloid receptor 1) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in other species including dog.

Reactivity

Human

Host

Rabbit

Epitope

Cytoplasmic Loop

Vial size

100 μL

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.

Handling

Avoid freeze and thaw cycles.

References

Submitted references

Molecular determinants of vanilloid sensitivity in TRPV1.

Gavva NR, Klionsky L, Qu Y, Shi L, Tamir R, Edenson S, Zhang TJ, Viswanadhan VN, Toth A, Pearce LV, Vanderah TW, Porreca F, Blumberg PM, Lile J, Sun Y, Wild K, Louis JC, Treanor JJ
The Journal of biological chemistry 2004 May 7;279(19):20283-95

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Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures.

Ständer S, Moormann C, Schumacher M, Buddenkotte J, Artuc M, Shpacovitch V, Brzoska T, Lippert U, Henz BM, Luger TA, Metze D, Steinhoff M
Experimental dermatology 2004 Mar;13(3):129-39

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TRPV3 is a temperature-sensitive vanilloid receptor-like protein.

Smith GD, Gunthorpe MJ, Kelsell RE, Hayes PD, Reilly P, Facer P, Wright JE, Jerman JC, Walhin JP, Ooi L, Egerton J, Charles KJ, Smart D, Randall AD, Anand P, Davis JB
Nature 2002 Jul 11;418(6894):186-90

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The tissue distribution and functional characterization of human VR1.

Cortright DN, Crandall M, Sanchez JF, Zou T, Krause JE, White G
Biochemical and biophysical research communications 2001 Mar;281(5):1183-9

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Pharmacological differences between the human and rat vanilloid receptor 1 (VR1).

McIntyre P, McLatchie LM, Chambers A, Phillips E, Clarke M, Savidge J, Toms C, Peacock M, Shah K, Winter J, Weerasakera N, Webb M, Rang HP, Bevan S, James IF
British journal of pharmacology 2001 Mar;132(5):1084-94

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Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A
Genome research 2001 Mar;11(3):422-35

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Cloning and functional expression of a human orthologue of rat vanilloid receptor-1.

Hayes P, Meadows HJ, Gunthorpe MJ, Harries MH, Duckworth DM, Cairns W, Harrison DC, Clarke CE, Ellington K, Prinjha RK, Barton AJ, Medhurst AD, Smith GD, Topp S, Murdock P, Sanger GJ, Terrett J, Jenkins O, Benham CD, Randall AD, Gloger IS, Davis JB
Pain 2000 Nov;88(2):205-15