Tissue expression
Cell line expression
Protein structure
KCNA5
Potassium voltage-gated channel subfamily A member 5HK2, HPCN1, Kv1.5
Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7). [provided by RefSeq, May 2012]
Top validated antibodies |
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Invitrogen Antibodies | PA5-109279 | Polyclonal |
WB
ICC
IHC
FC |
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Novus Biologicals | NBP2-76939 | Polyclonal |
WB
ICC
IHC
FC |
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GeneTex | GTX42027 | Monoclonal |
WB
ICC
IP
IHC |
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HUABIO Research | ER1803-23 | Polyclonal |
WB
ICC
IHC
FC |
||
Antibodies Incorporated / NeuroMab | 73-011 | Monoclonal |
WB
ICC
IP
|
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