APR00497G

KCNA5 antibody from Leading Biology
HK2, HPCN1, Kv1.5
Western blot
Recommended by provider
Immunoprecipitation
Recommended by provider

Antibody data

Product number
APR00497G
Provider
Leading Biology
Product name
KV1.5 Antibody
Provider product page
Leading Biology - APR00497G
Antibody type
Polyclonal
Description
KV1.5 is a mammalian voltage dependent K+ channel, homologous to the Drosophila Shaker K+ channel. KV1.5 was first cloned from rat brain.1 Eight Shaker related genes exist in mammals constituting the KV1, subfamily of the large KV channel family of genes.2A functional KV1 channel is either a membrane spanning homotetramer or heterotetramer, which is composed of members of the same subfamily. In addition several auxiliary subunits and intracellular proteins might interact with the channel and affect its function.The structure of KV1.5 channel is similar to all KV channels and includes six membrane spanning helixes creating a voltage sensor domain and a pore domain. 2The channel is expressed in cardiac and smooth muscle tissue (colon, aorta, stomach andpulmonary artery) as well as in neurons and kidney.2 A loss of function mutation in the gene encoding the channel was found in atrial fibrilation patients, stressing its role as a cardiac action potential regulator.3The functional channel is considered transient (A-type) channel and shows prominent inactivation. Therefore, this channel activity influences the membrane potential and excitability of neurons and muscle.KV1.5 channels are sensitive to high doses of TEA (330 mM) and low doses of 4-AP (0.27 mM), the “classical” non-selective potassium channel blockers.2
Reactivity
Human, Mouse, Rat
Host
Rabbit
Storage
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Provider Type Product Number
- No reagents -