66580-1-Ig

antibody from Proteintech Group

Targeting: NSUN2 FLJ20303, Misu, MRT5, TRM4

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

66580-1-Ig

Provider

Proteintech Group

Product name

NSUN2 antibody

Antibody type

Monoclonal

Description

NSUN2 antibody (Cat. #66580-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: IF, IHC, WB,ELISA.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

2H5A2

Vial size

20ul, 150ul

References

Submitted references

NCAPG confers ferroptosis resistance of hepatocellular carcinoma through NSUN2-mediated m5C modification.

Huang Z, Wang J, He A, Feng Q, Yang J, Wu L, Liao W
Cellular signalling 2026 Feb;138:112256

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Enhanced 5-methylcytosine methylation of PSD4 facilitates vasculogenic mimicry in breast cancer brain metastases through ferroptotic resistance.

Li M, Cui C, Li J, Zhou J, Chen S, Yan J, Zhang D, Zhang Y, Xie P, Yao Y, Ni F, An M, Zhang W, Fu B
Cellular signalling 2025 Nov;135:112022

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The m((5))C methyltransferase NSUN2 promotes progression of acute myeloid leukemia by regulating serine metabolism.

Li S, Liu Y, Wu X, Pan M, Zhao H, Hong Y, Zhang Q, Hu S, Ouyang A, Li G, Wu M, Fan S, Jia Z, Zhao S, Wu G, Gao X, Yang Z, Chen Z
Cell reports 2025 May 27;44(5):115661

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Hypoxia-induced NSUN2 promotes the progression of colon cancer by modulating the discrepant cleavage of tRNA-Arg.

Luan N, Cao Y, Sun J, Ye X, Zhou Q, Tang Z, Wang J
International immunopharmacology 2025 Aug 28;161:115023

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NSUN2 mediates distinct pathways to regulate enterovirus 71 replication.

Liu L, Chen Z, Zhang K, Hao H, Ma L, Liu H, Yu B, Ding S, Zhang X, Zhu M, Guo X, Liu Y, Liu H, Huang F, Peng K, Guan W
Virologica Sinica 2024 Aug;39(4):574-586

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NSUN2 is a glucose sensor suppressing cGAS/STING to maintain tumorigenesis and immunotherapy resistance.

Chen T, Xu ZG, Luo J, Manne RK, Wang Z, Hsu CC, Pan BS, Cai Z, Tsai PJ, Tsai YS, Chen ZZ, Li HY, Lin HK
Cell metabolism 2023 Oct 3;35(10):1782-1798.e8

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RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation.

Kim YA, Siddiqui T, Blaze J, Cosacak MI, Winters T, Kumar A, Tein E, Sproul AA, Teich AF, Bartolini F, Akbarian S, Kizil C, Hargus G, Santa-Maria I
Acta neuropathologica 2023 Jan;145(1):29-48

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N(6)-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis.

Chen RX, Chen X, Xia LP, Zhang JX, Pan ZZ, Ma XD, Han K, Chen JW, Judde JG, Deas O, Wang F, Ma NF, Guan X, Yun JP, Wang FW, Xu RH, Dan Xie
Nature communications 2019 Oct 16;10(1):4695