NSUN2

This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011]

Description

NOP2/Sun RNA methyltransferase 2

Protein family

Disease related genes, Enzymes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Potential drug targets, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

5:p15.31 (6599239 - 6633291)

Ensembl ID

ENSG00000037474  (ver. 99.38)

Orthologs

Mouse Nsun2: ENSMUSG00000021595

UniProt

Q08J23

neXtProt

NX_Q08J23

Human splice variants
Mouse splice variants