PLA2G6

The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010]

Description

phospholipase A2 group VI

Protein family

Disease related genes, Enzymes, FDA approved drug targets, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Predicted membrane proteins, Protein evidence (Peptideatlas), RAS pathway related proteins

Chromosome

22:q13.1 (38111495 - 38214778)

Ensembl ID

ENSG00000184381  (ver. 99.38)

Orthologs

Mouse Pla2g6: ENSMUSG00000042632

UniProt

O60733

neXtProt

NX_O60733

Human splice variants
Mouse splice variants