AGTO-G029D

antibody from Creative Biolabs

Targeting: FOLH1 FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA

No application information provided.

Antibody Data

Product number

AGTO-G029D

Provider

Creative Biolabs

Product name

Anti-FOLH1 immunotoxin D7 (scFv)-DT

Antibody type

Monoclonal

Description

This immunotoxin was achieved by conjugating/fusing the Anti-FOLH1 scFv to Diphtheria toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to prostate cancer cells and the toxin enters cells by receptor-mediated endocytosis. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death. It was designed for treatment of prostate cancer.

Reactivity

Human

Host

Mouse