FOLH1

gene product
FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
More gene data

Featured antibodies

Antibodies

 

Filters

Antibodypedia Validation Initiative

Validation method

Application

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Validated by best practice
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
651 antibodies from 31 providers.

Antibody properties

Applications

or Cancel
AntibodyRefsTypeAVIWBELICCIPIHCFC
Novus Biologicals
45 antibodies
antibodies-online
232 antibodies
OriGene
12 antibodies
R&D Systems
10 antibodies
Acris Antibodies GmbH
25 antibodies
GeneTex
16 antibodies
Aviva Systems Biology
13 antibodies
Abnova Corporation
18 antibodies
NovoPro Bioscience Inc.
11 antibodies
Invitrogen Antibodies
8 antibodies
Abgent
8 antibodies
Atlas Antibodies
1 antibody
NSJ Bioreagents
1 antibody
LifeSpan BioSciences, Inc.
84 antibodies
Arigo
8 antibodies
Proteintech Group
1 antibody
Biorbyt
18 antibodies
Creative Biolabs
6 antibodies
Cell Signaling Technology, Inc
2 antibodies
RabMAbs
6 antibodies
BioLegend
13 antibodies
MyBioSource
20 antibodies
RayBiotech, Inc.
6 antibodies
Creative Diagnostics
11 antibodies
GenWay
2 antibodies
United States Biological
49 antibodies
Spring Bioscience
8 antibodies
EMD Millipore
2 antibodies
Sigma-Aldrich
2 antibodies
St John's Laboratory
1 antibody