AGTO-G029E
antibody from Creative Biolabs
Targeting: FOLH1
FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA
Antibody data
- Antibody Data
- Antigen structure
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- Product number
- AGTO-G029E - Provider product page
- Provider
- Creative Biolabs
- Product name
- Anti-FOLH1 immunotoxin D7 (scFv)-PE
- Antibody type
- Monoclonal
- Description
- This immunotoxin was achieved by conjugating/fusing the Anti-FOLH1 scFv to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to prostate cancer cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating prostate cancer.
- Reactivity
- Human
- Host
- Mouse
- Antibody clone number
- D7
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