Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS60118 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- AXIN1 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human AXIN1.
- Description
- ÉÇ-catenin is a component of both the cadherin cell adhesion system and the Wnt signaling pathway. Wnt signaling increases the amount of ÉÇ-catenin by preventing its ubiquitination and degradation, allowing its direct interaction with transcription factors of the lymphoid enhancer factor/T cell factor family, and modulation of gene expression. Axin is involved in the degradation of ÉÇ-catenin by acting as a scaffold to form a complex between ÉÇ-catenin, adenomatous polyposis coli (APC) and GSK-3ÉÇ. APC, which is phosphorylated by GSK-3ÉÇ, induces degradation of ÉÇ-catenin, thus inhibiting Wnt signal transduction. Conductin is 45% identical to Axin and appears to play a similar role to Axin in the Wnt signaling pathway.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot (WB) analysis of AXIN1 pAb at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:NIH-3T3 whole cell lysateLane3:PC12 whole cell lysate