SCAMP4

Secretory carrier membrane proteins (SCAMPs) are widely distributed integral membrane proteins implicated in membrane trafficking. Most SCAMPs (e.g., SCAMP1; MIM 606911) have N-terminal cytoplasmic NPF (arg-pro-phe) repeats, 4 central transmembrane regions, and a short C-terminal cytoplasmic tail. These SCAMPs likely have a role in endocytosis that is mediated by their NPF repeats. Other SCAMPs, such as SCAMP4, lack the NPF repeats and are therefore unlikely to function in endocytosis (summary by Fernandez-Chacon and Sudhof, 2000 [PubMed 11050114]). [supplied by OMIM, Feb 2011]

Description

Secretory carrier membrane protein 4

Tissue specificity

Low tissue specificity

Subcell location

Golgi apparatus, Vesicles, Lipid droplets, Plasma membrane

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

19 (1905372 - 1926013)

Ensembl ID

ENSG00000227500  (ver. 103.38)

Orthologs

Mouse Scamp4: ENSMUSG00000113949

UniProt

Q969E2

neXtProt

NX_Q969E2

Human splice variants
Mouse splice variants

Protein structure