BS8346

antibody from Bioworld Technology, Inc
Targeting: NSFL1C dJ776F14.1, p47, UBX1, UBXD10, UBXN2C
Provider product page for BS8346
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8346 - Provider product page
Provider
Bioworld Technology, Inc
Product name
NSFL1C polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human NSFL1C.
Description
p47, also known as NSFL1C, UBX1, UBXD10 or UBXN2C, is a 370 amino acid protein that localizes to both the nucleus and the golgi apparatus (specifically to golgi stacks) and contains one SEP domain and one UBX domain. Functioning as part of a ternary complex with VCP (a protein involved in the heterotypic fusion of transport vesicles with their target membranes) and Syntaxin 5, p47 interacts with and reduces the ATPase activity of VCP and is required for the fragmentation of golgi stacks during mitosis and for subsequent reassembly of golgi stacks after mitosis. p47 is subject to phosphorylation during mitosis, which inhibits p47-golgi interaction and is, therefore, required for proper golgi stack formation and cisternal regrowth. Human p47 shares 89% sequence identity with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of p47 exist due to alternative splicing events.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
NSFL1C protein structure - BS8346 shown in red.