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Protein structure
TLE6
TLE family member 6, subcortical maternal complex memberFLJ14009, GRG6
This gene encodes a member of the Groucho/ transducin-like Enhancer of split family of transcriptional co-repressors. The encoded protein is a component of the mammalian subcortical maternal complex, which is required for preimplantation development. In mouse, knock out of this gene results in cleavage-stage embryonic arrest resulting from defective cytoplasmic F-actin meshwork formation and asymmetric cell division. In human, an allelic variant in this gene is associated with preimplantation embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Top validated antibodies |
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| Novus Biologicals |  H00079816-M01 |
1 references | Monoclonal |
WB
EL
ICC
IHC
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| Invitrogen Antibodies | PA5-109241 |
Polyclonal |
WB
ICC
IHC
FC
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| HUABIO Research | ER1802-58 |
Polyclonal |
WB
ICC
IHC
FC
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| LSBio | LS-C161914 |
Polyclonal |
WB
IHC
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| NSJ Bioreagents | F43005 |
Polyclonal |
WB
EL
IHC
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