Tissue expression
Cell line expression
Protein structure
SIM2
SIM bHLH transcription factor 2bHLHe15, MGC119447, SIM
This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Top validated antibodies |
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Proteintech Group | ![]() |
1 references | Polyclonal |
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FineTest Biotech | ![]() |
Polyclonal |
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Biorbyt | ![]() |
Polyclonal |
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Invitrogen Antibodies | ![]() |
Polyclonal |
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Novus Biologicals | ![]() |
1 references | Polyclonal |
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