10862-1-AP

antibody from Proteintech Group

Targeting: ENG CD105, END, HHT1, ORW, ORW1

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunoprecipitation (Supportive data in Antibodypedia)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

10862-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#10862-1-AP, RRID:AB_2098906

Product name

Endoglin/CD105 antibody

Antibody type

Polyclonal

Description

Endoglin/CD105 antibody (Cat. #10862-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Lyophilizable Stem Cell-Hybrid Liposome with Long-Term Stability and High Targeting Capacity.

Zhang T, Zheng X, Lin R, Sun H, Wu H, Zhang J, Chen S, Li Y, Xu D, Gao J
Advanced healthcare materials 2024 Sep;13(22):e2400704

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Tobacco toxins trigger bone marrow mesenchymal stem cells aging by inhibiting mitophagy.

Xiang K, Ren M, Liu F, Li Y, He P, Gong X, Chen T, Wu T, Huang Z, She H, Liu K, Jing Z, Yang S
Ecotoxicology and environmental safety 2024 Jun 1;277:116392

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Inhibition of cGAS-STING pathway by stress granules after activation of M2 macrophages by human mesenchymal stem cells against drug induced liver injury.

Wang Y, She S, Li W, Zhu J, Li X, Yang F, Dai K
Molecular immunology 2024 Jan;165:42-54

---

The ENG/VEGFα Pathway Is Likely Affected by a Nonsense Variant of Endoglin (ENG)/CD105, Causing Hereditary Hemorrhagic Telangiectasia Type 1 (HHT1) in a Chinese Family.

Liu K, Fu J, Guo K, Maghsoudloo M, Cheng J, Fu J
Genes 2024 Feb 27;15(3)

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Biological characteristics of Muse cells derived from MenSCs and their application in acute liver injury and intracerebral hemorrhage diseases.

Li H, Wei J, Li M, Li Y, Zhang T, Tian J, Liu X, Li K, Lin J
Regenerative therapy 2024 Dec;27:48-62

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Phenotypic and Functional Characterization of Bovine Adipose-Derived Mesenchymal Stromal Cells.

Maldonado VV, Pokharel S, Powell JG, Samsonraj RM
Animals : an open access journal from MDPI 2024 Apr 25;14(9)

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LncRNA PVT1 promotes strong stemness and endothelial progenitor cell characteristics in renal carcinoma stem cells.

Wang L, Yang G, Guo P, Lv Y, Fu B, Bai Y, Xiong F, Zhao D, Li C, Zhang J, Bai S, Zeng F, Xu W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Sep;37(9):e23118

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Catalpol Alleviates Ischemic Stroke Through Promoting Angiogenesis and Facilitating Proliferation and Differentiation of Neural Stem Cells via the VEGF-A/KDR Pathway.

Sun S, Xu Y, Yu N, Zhang M, Wang J, Wan D, Tian Z, Zhu H
Molecular neurobiology 2023 Nov;60(11):6227-6247

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Initial and ongoing tobacco smoking elicits vascular damage and distinct inflammatory response linked to neurodegeneration.

Garza AP, Morton L, Pállinger É, Buzás EI, Schreiber S, Schott BH, Dunay IR
Brain, behavior, & immunity - health 2023 Mar;28:100597

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METTL3 promotes SMSCs chondrogenic differentiation by targeting the MMP3, MMP13, and GATA3.

Hu B, Zou X, Yu Y, Jiang Y, Xu H
Regenerative therapy 2023 Mar;22:148-159

---

Resveratrol May Reduce the Degree of Periodontitis by Regulating ERK Pathway in Gingival-Derived MSCs.

Jiang H, Ni J, Hu L, Xiang Z, Zeng J, Shi J, Chen Q, Li W
International journal of molecular sciences 2023 Jul 10;24(14)

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Quercetin ameliorates oxidative stress-induced senescence in rat nucleus pulposus-derived mesenchymal stem cells via the miR-34a-5p/SIRT1 axis.

Zhao WJ, Liu X, Hu M, Zhang Y, Shi PZ, Wang JW, Lu XH, Cheng XF, Tao YP, Feng XM, Wang YX, Zhang L
World journal of stem cells 2023 Aug 26;15(8):842-865

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GATA6 coordinates cross-talk between BMP10 and oxidative stress axis in pulmonary arterial hypertension.

Toyama T, Kudryashova TV, Ichihara A, Lenna S, Looney A, Shen Y, Jiang L, Teos L, Avolio T, Lin D, Kaplan U, Marden G, Dambal V, Goncharov D, Delisser H, Lafyatis R, Seta F, Goncharova EA, Trojanowska M
Scientific reports 2023 Apr 22;13(1):6593

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Appropriate Dose of Dapagliflozin Improves Cardiac Outcomes by Normalizing Mitochondrial Fission and Reducing Cardiomyocyte Apoptosis After Acute Myocardial Infarction.

Fan ZG, Xu Y, Chen X, Ji MY, Ma GS
Drug design, development and therapy 2022;16:2017-2030

---

Endoglin aggravates peritoneal fibrosis by regulating the activation of TGF-β/ALK/Smads signaling.

Huang Q, Xiao R, Lu J, Zhang Y, Xu L, Gao J, Sun J, Wang H
Frontiers in pharmacology 2022;13:973182

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Response of TGF-β isoforms in epithelial-mesenchymal transition of enamel epithelial cells.

Miyakawa Y, Chiba-Ohkuma R, Karakida T, Yamamoto R, Kobayashi S, Yamakoshi Y, Asada Y
Archives of oral biology 2022 Nov;143:105540

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Cancer-associated fibroblasts promote the stemness and progression of renal cell carcinoma via exosomal miR-181d-5p.

Ding M, Zhao X, Chen X, Diao W, Kan Y, Cao W, Chen W, Jiang B, Qin H, Gao J, Zhuang J, Zhang Q, Guo H
Cell death discovery 2022 Nov 1;8(1):439

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The additive effects of photobiomodulation and bioactive glasses on enhancing early angiogenesis.

Huang L, Gong W, Huang G, Li J, Wu J, Wang Y, Dong Y
Biomedical materials (Bristol, England) 2022 May 13;17(4)

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WISP2/CCN5 Suppresses Vasculogenic Mimicry through Inhibition of YAP/TAZ Signaling in Breast Cancer Cells.

Ferrand N, Fert A, Morichon R, Radosevic-Robin N, Zaoui M, Sabbah M
Cancers 2022 Mar 14;14(6)

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Regulation of Blood-Brain Barrier Transporters by Transforming Growth Factor-β/Activin Receptor-Like Kinase 1 Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors (i.e., Statins).

Betterton RD, Abdullahi W, Williams EI, Lochhead JJ, Brzica H, Stanton J, Reddell E, Ogbonnaya C, Davis TP, Ronaldson PT
Drug metabolism and disposition: the biological fate of chemicals 2022 Jul;50(7):942-956

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Endoglin Modulates TGFβR2 Induced VEGF and Proinflammatory Cytokine Axis Mediated Angiogenesis in Prolonged DEHP-Exposed Breast Cancer Cells.

Jadhao M, Chen CL, Liu W, Deshmukh D, Liao WT, Chen JY, Urade R, Tsai EM, Hsu SK, Wang LF, Chiu CC
Biomedicines 2022 Feb 10;10(2)

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Roquin2 suppresses breast cancer progression by inhibiting tumor angiogenesis via selectively destabilizing proangiogenic factors mRNA.

Zhou M, Lu W, Li B, Yuan X, Liu M, Han J, Liu X, Li A
International journal of biological sciences 2021;17(11):2884-2898

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Umbilical artery tissue contains p75 neurotrophin receptor-positive pericyte-like cells that possess neurosphere formation capacity and neurogenic differentiation potential.

Fujii-Tezuka R, Ishige-Wada M, Nagoshi N, Okano H, Mugishima H, Takahashi S, Morioka I, Matsumoto T
Regenerative therapy 2021 Mar;16:1-11

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Urolithin a alleviates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells through SIRT1/PGC-1α pathway.

Shi PZ, Wang JW, Wang PC, Han B, Lu XH, Ren YX, Feng XM, Cheng XF, Zhang L
World journal of stem cells 2021 Dec 26;13(12):1928-1946

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Human umbilical cord mesenchymal stem cells regulate CD54 and CD105 in vascular endothelial cells and suppress inflammation in Kawasaki disease.

Chen T, Xu T, Cheng M, Fang H, Shen X, Tang Z, Zhao J
Experimental cell research 2021 Dec 15;409(2):112941

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Inhibition of DNA Methyltransferase by RG108 Promotes Pluripotency-Related Character of Porcine Bone Marrow Mesenchymal Stem Cells.

Li Q, Zhai Y, Man X, Zhang S, An X
Cellular reprogramming 2020 Apr;22(2):82-89

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MMP-14 aggravates onset of severe preeclampsia by mediating soluble endoglin release.

Zhang XH, Zhang HY, Lu S, Jiang LL, Wu J, Yang YL, Zhang SA
European review for medical and pharmacological sciences 2018 Mar;22(5):1209-1215

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Inhibiting transforming growth factor-β signaling regulates in vitro maintenance and differentiation of bovine bone marrow mesenchymal stem cells.

Zhao XX, An XL, Zhu XC, Jiang Y, Zhai YH, Zhang S, Cai NN, Tang B, Li ZY, Zhang XM
Journal of experimental zoology. Part B, Molecular and developmental evolution 2018 Dec;330(8):406-416

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Imbalance of angiogenic factors and avascular edematous cystic villi in a trisomy 13 pregnancy: a case report.

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Placenta 2013 Jul;34(7):628-30

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Placental expression of anti-angiogenic proteins in mirror syndrome: a case report.

Graham N, Garrod A, Bullen P, Heazell AE
Placenta 2012 Jun;33(6):528-31

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Oxidative stress-induced S100B protein from placenta and amnion affects soluble Endoglin release from endothelial cells.

Tskitishvili E, Sharentuya N, Temma-Asano K, Mimura K, Kinugasa-Taniguchi Y, Kanagawa T, Fukuda H, Kimura T, Tomimatsu T, Shimoya K
Molecular human reproduction 2010 Mar;16(3):188-99

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

mouse lung tissue were subjected to SDS PAGE followed by western blot with 10862-1-AP(ENG antibody) at dilution of 1:300

Sample type

tissue

Immunoprecipitation

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

IP Result of anti-ENG (IP:10862-1-AP, 3ug; Detection:10862-1-AP 1:300) with mouse lung tissue lysate 4000ug.

Sample type

tissue

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human placenta using 10862-1-AP(ENG antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The Endoglin/CD105 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Endoglin/CD105. This antibody recognizes human,mouse,rat antigen. The Endoglin/CD105 antibody has been validated for the following applications: ELISA, WB, IP, IHC analysis.

Appendix

10862-1-AP.pdf

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