CABT-B068

antibody from Creative Diagnostics

Targeting: ENG CD105, END, HHT1, ORW, ORW1

Western blot (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

CABT-B068

Provider

Creative Diagnostics

Product name

Anti-ENG monoclonal antibody, clone 55H5

Antibody type

Monoclonal

Description

Endoglin (CD105) is a homodimeric integral membrane glycoprotein comprised of a 95 kDa subunit. Endoglin is a component of the Transforming Growth Factor beta (TGF-ÉÇ) receptor system that functions as an ancillary receptor influencing binding of the TGF-ÉÇ family of ligands to signaling receptors. Endoglin binds to TGF-ÉÇ1 and TGF-ÉÇ3 with high affinity, but does not bind TGF-ÉÇ2. Endoglin is expressed by vascular endothelial cells and syncytiotrophoblasts of placenta and is weakly expressed by stromalfibroblasts. Endoglin is also expressed by U937 cells and by activated macrophages. Endoglin expression is up-regulated on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG