BS7918

antibody from Bioworld Technology, Inc
Targeting: KLRK1 CD314, D12S2489E, KLR, NKG2-D, NKG2D
Provider product page for BS7918
Western blot
Immunohistochemistry

Antibody data

Product number
BS7918 - Provider product page
Provider
Bioworld Technology, Inc
Product name
KLRK1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human KLRK1.
Description
The activity of natural killer (NK) cells is regulated by members of multiple receptor families that recognize class I MHC molecules, such as the killer cell inhibitory receptor/leukocyte immunoglobulin-like receptor (KIR/LIR) family and the C-type lectin superfamily. The KIR/LIR family includes p91A (also designated pp130 or PIR-B, for paired Immunoglobulin-like receptor-B) and p91B (also designated PIR-A). p91A acts as an inhibitory receptor through interactions with SHP-1, whereas p91B acts as an activating receptor. CD94, NKG2 and Ly-49 are members of the C-type lectin superfamily of type II membrane glycoproteins. CD94 forms heterodimers with NKG2 isoforms on the surface of NK cells, whereas Ly-49 isoforms form homodimers. NKG2-D, expressed on NK cells, ÎÛÑ´ T cells, and CD8+ Ï«ÉÇ T cells, is a receptor for the stress inducible protein MICA, an antigen frequently expressed in epithelial tumors.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
KLRK1 protein structure - BS7918 shown in red.