KLRK1

gene product
CD314, D12S2489E, KLR, NKG2-D, NKG2D
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
647 antibodies from 32 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Novus Biologicals
37 antibodies
R&D Systems
21 antibodies
antibodies-online
184 antibodies
Invitrogen Antibodies
24 antibodies
GeneTex
17 antibodies
Biorbyt
39 antibodies
LifeSpan BioSciences, Inc.
101 antibodies
Affinity Biosciences
1 antibody
Abnova Corporation
6 antibodies
Bioworld Technology, Inc
1 antibody
Acris Antibodies GmbH
15 antibodies
Abbkine Scientific Co.Ltd.
2 antibodies
BioLegend
21 antibodies
Creative Biolabs
67 antibodies
Aviva Systems Biology
4 antibodies
NSJ Bioreagents
2 antibodies
Everest Biotech
1 antibody
OriGene
4 antibodies
Arigo
6 antibodies
FabGennix
3 antibodies
Atlas Antibodies
1 antibody
Miltenyi Biotec
36 antibodies
Abbexa
8 antibodies
St John's Laboratory
2 antibodies
Creative Diagnostics
11 antibodies
Boster Biological Technology
1 antibody
ProSci
1 antibody
United States Biological
25 antibodies
MyBioSource
3 antibodies
BioLegend (formerly Covance Antibody Products)
1 antibody
EMD Millipore
1 antibody
Sigma-Aldrich
1 antibody