KLRK1

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010]

Description

Killer cell lectin like receptor K1

Tissue specificity

Tissue enhanced (bone marrow, lymphoid tissue)

Subcell location

Plasma membrane

Predicted location

Membrane

Protein family

Cancer-related genes
CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Transporters

Chromosome

12 (10372353 - 10391874)

Ensembl ID

ENSG00000213809  (ver. 103.38)

Orthologs

Mouse Klrk1: ENSMUSG00000030149

UniProt

P26718

neXtProt

NX_P26718

Human splice variants
Mouse splice variants

Protein structure