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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [5]
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- Validations
- Immunohistochemistry [1]
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- Product number
- 200-301-397 - Provider product page
- Provider
- Rockland Immunochemicals, Inc.
- Proper citation
- Rockland Cat#200-301-397, RRID:AB_2255063
- Product name
- Anti-SMC1 pS957 (MOUSE) Monoclonal Antibody - 200-301-397
- Antibody type
- Monoclonal
- Vial size
- 100 µl
Submitted references The deacetylation-phosphorylation regulation of SIRT2-SMC1A axis as a mechanism of antimitotic catastrophe in early tumorigenesis.
Sodium tungstate modulates ATM function upon DNA damage.
Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes.
ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway.
Yi F, Zhang Y, Wang Z, Wang Z, Li Z, Zhou T, Xu H, Liu J, Jiang B, Li X, Wang L, Bai N, Guo Q, Guan Y, Feng Y, Mao Z, Fan G, Zhang S, Wang C, Cao L, O'Rourke BP, Wang Y, Wu Y, Wu B, You S, Zhang N, Guan J, Song X, Sun Y, Wei S, Cao L
Science advances 2021 Feb;7(9)
Science advances 2021 Feb;7(9)
Sodium tungstate modulates ATM function upon DNA damage.
Rodriguez-Hernandez CJ, Llorens-Agost M, Calbó J, Murguia JR, Guinovart JJ
FEBS letters 2013 May 21;587(10):1579-86
FEBS letters 2013 May 21;587(10):1579-86
Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes.
Callén E, Jankovic M, Wong N, Zha S, Chen HT, Difilippantonio S, Di Virgilio M, Heidkamp G, Alt FW, Nussenzweig A, Nussenzweig M
Molecular cell 2009 May 15;34(3):285-97
Molecular cell 2009 May 15;34(3):285-97
ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.
Pusapati RV, Rounbehler RJ, Hong S, Powers JT, Yan M, Kiguchi K, McArthur MJ, Wong PK, Johnson DG
Proceedings of the National Academy of Sciences of the United States of America 2006 Jan 31;103(5):1446-51
Proceedings of the National Academy of Sciences of the United States of America 2006 Jan 31;103(5):1446-51
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway.
Kitagawa R, Bakkenist CJ, McKinnon PJ, Kastan MB
Genes & development 2004 Jun 15;18(12):1423-38
Genes & development 2004 Jun 15;18(12):1423-38
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Supportive validation
- Submitted by
- Rockland Immunochemicals, Inc. (provider)
- Main image
- Experimental details
- Rockland's Protein G Purified Mab anti-SMC1 pS957 antibody was used at a 2.5 µg/ml to detect nuclear signal in a variety of tissues including multi-human, multi-brain and multi-cancer slides. This image shows moderate to strong nuclear anti-SMC1 pS957 staining of human breast ductal epithelium. Tissue was formalin-fixed and paraffin embedded. The image shows localization of the antibody as the precipitated red signal, with a hematoxylin purple nuclear counterstain. Personal Communication, Tina Roush, LifeSpanBiosciences, Seattle, WA.
- Validation comment
- Immunohistochemistry
