Tissue expression
Cell line expression
Protein structure
TJP3
Tight junction protein 3ZO-3
The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1. [provided by RefSeq, May 2012]
Top validated antibodies |
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Invitrogen Antibodies | 36-4000 | 5 references | Polyclonal |
WB
EL
ICC
IP
IHC
OA |
|
LSBio | LS-C354927 | Polyclonal |
WB
EL
ICC
IP
IHC
|
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Atlas Antibodies | HPA053337 | Polyclonal |
ICC
IHC |
||
Proteintech Group | 22116-1-AP | 1 references | Polyclonal |
WB
EL |
|
antibodies-online | ABIN955227 | 3 references | Polyclonal |
WB
|
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