12918-1-AP

antibody from Proteintech Group

Targeting: PDE4D DPDE3

Provider product page for 12918-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [32]
Comments [0]
Validations
Western blot [1]

Submit

Product number: 12918-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12918-1-AP, RRID:AB_2161097
Product name: PDE4D antibody
Antibody type: Polyclonal
Description: KD/KO validated PDE4D antibody (Cat. #12918-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PDE4D protein structure - 12918-1-AP shown in red.

Submitted references TRPS1 confers paclitaxel resistance in TNBC through dual activation of the PDE4D-cAMP-AKT pathway and microtubule destabilization.

He X, Tong W, Chen X, Huang H, Wei N, Ma J, Liu Y, Ma Y, Li S, Li W, Li H, Ren H
Breast cancer research : BCR 2026 Jan 20;28(1):47

Mechanism of Huanglian Zhimu Decoction in improving hepatic lipid deposition in type 2 diabetes based on lipidomics and transcriptomics.

Tu W, Tian X, Fu H, Xu F, Wang H, Wang Q, Lin X, Shu J, Lin S, Cao L, Wang L
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120309

Phosphodiesterase 4D protects against embryo loss via KLF4-IFITM3 axis during viral infection.

Chen Y, Shen K, Zhan W, Chen Q, Chen H, Zheng Q
International immunopharmacology 2025 Oct 10;163:115264

Linarin alleviates high-fat diet-induced hepatic steatosis by inhibiting PDE4D and activating the cAMP/PKA/CREB pathway.

Xiao Y, Wang J, Zhang H, Yang X, Zhou J, Zhou Y, Liu S, Liu M, Wang Y, Wang Y, Liao Q, Hou M, Hao Y, Liu S, Luo Z, Zhang S, Yu J, Yu L, Zhou L, Li Y, Li G
Free radical biology & medicine 2025 Nov;239:116-129

Single-nucleus transcriptomics reveals subsets of degenerative myonuclei after rotator cuff tear-induced muscle atrophy.

Sun Z, Cheng X, Wang Z, Qiao C, Qian H, Yuan T, Lv Z, Sun W, Zhang H, Liu Y, Lu Z, Lin J, Lai C, Wang Y, Yang X, Wang X, Meng J, Bao N
Cell proliferation 2025 Mar;58(3):e13763

Adipocyte-derived shed Syndecan-4 suppresses lipolysis contributing to impaired adipose tissue browning and adaptive thermogenesis.

Zong J, Wu X, Huang X, Yuan L, Yuan K, Zhang Z, Jiang M, Ping Z, Cheong LY, Xu A, Hoo RLC
Molecular metabolism 2025 Jun;96:102133

A novel phosphodiesterase 4/5 dual-target inhibitor ameliorates neuroinflammation via the NF-κB and JNK pathway.

Zhao L, Jiang W, Cao Y, Huang YY, Wang X, Guo L, Yu D, Shi J
International journal of biological macromolecules 2025 Jul;318(Pt 1):145007

Cinobufagin Directly Targets PDE4D to Disrupt Fibroblast-Dendritic Cell Crosstalk in Atopic Dermatitis.

Li S, Xu D, Zhang C, Xiao C, Yu M, Wang J, Wu W, Lv X, Yuan D, Zhang L, Hong M, Zhou J, Sun Y, Ma H, Zhu Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(48):e01670

Pan-Cancer Analysis of Cyclic Nucleotide Phosphodiesterases (PDEs) Expression, Variation, and Prognostic Significance.

Wu Z, Ren H, Guo F
ACS omega 2025 Dec 23;10(50):61247-61255

PDE4D drives rewiring of the MAPK pathway in BRAF-mutated melanoma resistant to MAPK inhibitors.

Delyon J, Becherirat S, Roger A, Bernard-Cacciarella M, Reger De Moura C, Louveau B, Mourah S, Lebbé C, Dumaz N
Cell communication and signaling : CCS 2024 Nov 21;22(1):559

GNAS mutation inhibits growth and induces phosphodiesterase 4D expression in colorectal cancer cell lines.

Nummela P, Zafar S, Veikkolainen E, Ukkola I, Cinella V, Ayo A, Asghar MY, Välimäki N, Törnquist K, Karhu A, Laakkonen P, Aaltonen LA, Ristimäki A
International journal of cancer 2024 Jun 1;154(11):1987-1998

Endoplasmic reticulum stress in pancreatic β cells induces incretin desensitization and β-cell dysfunction via ATF4-mediated PDE4D expression.

Lee JH, Ryu H, Lee H, Yu HR, Gao Y, Lee KM, Kim YJ, Lee J
American journal of physiology. Endocrinology and metabolism 2023 Nov 1;325(5):E448-E465

An Artemisia scoparia extract attenuates glucocorticoid-induced lipolysis in adipocytes.

Harvey I, Stephens JM
Obesity (Silver Spring, Md.) 2023 Jul;31(7):1859-1870

Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth.

Jeong MH, Urquhart G, Lewis C, Chi Z, Jewell JL
JCI insight 2023 Jul 10;8(13)

PDE4D/cAMP/IL-23 axis determines the immunotherapy efficacy of lung adenocarcinoma via activating the IL-9 autocrine loop of cytotoxic T lymphocytes.

Feng B, Pan B, Huang J, Du Y, Wang X, Wu J, Ma R, Shen B, Huang G, Feng J
Cancer letters 2023 Jul 1;565:216224

Synergistic effect of constituent drugs of Baibutang on improving Yin-deficiency pulmonary fibrosis in rats.

Fu S, Song X, Tang X, Qian X, Du Z, Hu Y, Xu X, Zhang M
Journal of ethnopharmacology 2023 Apr 24;306:116050

Overexpression of PDE4D in mouse liver is sufficient to trigger NAFLD and hypertension in a CD36-TGF-β1 pathway: therapeutic role of roflumilast.

Tao X, He H, Peng J, Xu R, Fu J, Hu Y, Li L, Yang X, Feng X, Zhang C, Zhang L, Yu X, Shen A, Huang K, Fu Q
Pharmacological research 2022 Jan;175:106004

Targeting PDE4 as a promising therapeutic strategy in chronic ulcerative colitis through modulating mucosal homeostasis.

Li H, Zhang Y, Liu M, Fan C, Feng C, Lu Q, Xiang C, Lu H, Yang X, Wu B, Zou D, Tang W
Acta pharmaceutica Sinica. B 2022 Jan;12(1):228-245

FGF1 and insulin control lipolysis by convergent pathways.

Sancar G, Liu S, Gasser E, Alvarez JG, Moutos C, Kim K, van Zutphen T, Wang Y, Huddy TF, Ross B, Dai Y, Zepeda D, Collins B, Tilley E, Kolar MJ, Yu RT, Atkins AR, van Dijk TH, Saghatelian A, Jonker JW, Downes M, Evans RM
Cell metabolism 2022 Jan 4;34(1):171-183.e6

PDE4D binds and interacts with YAP to cooperatively promote HCC progression.

Ren H, Chen Y, Ao Z, Cheng Q, Yang X, Tao H, Zhao L, Shen A, Li P, Fu Q
Cancer letters 2022 Aug 10;541:215749

MicroRNA-137-3p Improves Nonalcoholic Fatty Liver Disease through Activating AMPKα.

Yu Y, He C, Tan S, Huang M, Guo Y, Li M, Zhang Q
Analytical cellular pathology (Amsterdam) 2021;2021:4853355

Evidence for reprogramming of monocytes into reparative alveolar macrophages in vivo by targeting PDE4b.

Rochford I, Joshi JC, Rayees S, Anwar M, Akhter MZ, Yalagala L, Banerjee S, Mehta D
American journal of physiology. Lung cellular and molecular physiology 2021 Oct 1;321(4):L686-L702

Hyperinsulinemia promotes heterologous desensitization of β(2) adrenergic receptor in airway smooth muscle in obesity.

Xu R, Gopireddy RR, Wu Y, Wu L, Tao X, Shao J, Wang W, Li L, Jovanovic A, Xu B, Kenyon NJ, Lu Q, Xiang YK, Fu Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):3996-4008

Inhibition of PDE4/PDE4B improves renal function and ameliorates inflammation in cisplatin-induced acute kidney injury.

Xu M, Yu X, Meng X, Huang S, Zhang Y, Zhang A, Jia Z
American journal of physiology. Renal physiology 2020 Mar 1;318(3):F576-F588

Upregulation of miR-219a-5p Decreases Cerebral Ischemia/Reperfusion Injury In Vitro by Targeting Pde4d.

Lu MY, Wu JR, Liang RB, Wang YP, Zhu YC, Ma ZT, Zhang H, Zan J, Tan W
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2020 Jun;29(6):104801

DC591017, a phosphodiesterase-4 (PDE4) inhibitor with robust anti-inflammation through regulating PKA-CREB signaling.

Li H, Li J, Zhang X, Feng C, Fan C, Yang X, Zhang R, Zhu F, Zhou Y, Xu Y, Liu H, Tang W
Biochemical pharmacology 2020 Jul;177:113958

High expression of PDE4D correlates with poor prognosis and clinical progression in pancreaticductal adenocarcinoma.

Liu F, Ma J, Wang K, Li Z, Jiang Q, Chen H, Li W, Xia J
Journal of Cancer 2019;10(25):6252-6260

Inhibition of phosphodiesterase-4 attenuates murine ulcerative colitis through interference with mucosal immunity.

Li H, Fan C, Feng C, Wu Y, Lu H, He P, Yang X, Zhu F, Qi Q, Gao Y, Zuo J, Tang W
British journal of pharmacology 2019 Jul;176(13):2209-2226

Molecular inotropy mediated by cardiac miR-based PDE4D/PRKAR1α/phosphoprotein signaling.

Bedada FB, Martindale JJ, Arden E, Metzger JM
Scientific reports 2016 Nov 11;6:36803

Salt-Inducible Kinase 1 Terminates cAMP Signaling by an Evolutionarily Conserved Negative-Feedback Loop in β-Cells.

Kim MJ, Park SK, Lee JH, Jung CY, Sung DJ, Park JH, Yoon YS, Park J, Park KG, Song DK, Cho H, Kim ST, Koo SH
Diabetes 2015 Sep;64(9):3189-202

miR-199a Links MeCP2 with mTOR Signaling and Its Dysregulation Leads to Rett Syndrome Phenotypes.

Tsujimura K, Irie K, Nakashima H, Egashira Y, Fukao Y, Fujiwara M, Itoh M, Uesaka M, Imamura T, Nakahata Y, Yamashita Y, Abe T, Takamori S, Nakashima K
Cell reports 2015 Sep 22;12(11):1887-901

Interplay between the E2F pathway and β-adrenergic signaling in the pathological hypertrophic response of myocardium.

Major JL, Salih M, Tuana BS
Journal of molecular and cellular cardiology 2015 Jul;84:179-90

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The PDE4D antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PDE4D. This antibody recognizes human,mouse,rat antigen. The PDE4D antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 12918-1-AP.pdf

: Show more