Antibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 12918-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12918-1-AP, RRID:AB_2161097
- Product name
- PDE4D antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PDE4D antibody (Cat. #12918-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references GNAS mutation inhibits growth and induces phosphodiesterase 4D expression in colorectal cancer cell lines.
Endoplasmic reticulum stress in pancreatic β cells induces incretin desensitization and β-cell dysfunction via ATF4-mediated PDE4D expression.
An Artemisia scoparia extract attenuates glucocorticoid-induced lipolysis in adipocytes.
Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth.
PDE4D/cAMP/IL-23 axis determines the immunotherapy efficacy of lung adenocarcinoma via activating the IL-9 autocrine loop of cytotoxic T lymphocytes.
Synergistic effect of constituent drugs of Baibutang on improving Yin-deficiency pulmonary fibrosis in rats.
Overexpression of PDE4D in mouse liver is sufficient to trigger NAFLD and hypertension in a CD36-TGF-β1 pathway: therapeutic role of roflumilast.
Targeting PDE4 as a promising therapeutic strategy in chronic ulcerative colitis through modulating mucosal homeostasis.
FGF1 and insulin control lipolysis by convergent pathways.
PDE4D binds and interacts with YAP to cooperatively promote HCC progression.
MicroRNA-137-3p Improves Nonalcoholic Fatty Liver Disease through Activating AMPKα.
Evidence for reprogramming of monocytes into reparative alveolar macrophages in vivo by targeting PDE4b.
Hyperinsulinemia promotes heterologous desensitization of β(2) adrenergic receptor in airway smooth muscle in obesity.
Inhibition of PDE4/PDE4B improves renal function and ameliorates inflammation in cisplatin-induced acute kidney injury.
Upregulation of miR-219a-5p Decreases Cerebral Ischemia/Reperfusion Injury In Vitro by Targeting Pde4d.
DC591017, a phosphodiesterase-4 (PDE4) inhibitor with robust anti-inflammation through regulating PKA-CREB signaling.
High expression of PDE4D correlates with poor prognosis and clinical progression in pancreaticductal adenocarcinoma.
Inhibition of phosphodiesterase-4 attenuates murine ulcerative colitis through interference with mucosal immunity.
Molecular inotropy mediated by cardiac miR-based PDE4D/PRKAR1α/phosphoprotein signaling.
Salt-Inducible Kinase 1 Terminates cAMP Signaling by an Evolutionarily Conserved Negative-Feedback Loop in β-Cells.
miR-199a Links MeCP2 with mTOR Signaling and Its Dysregulation Leads to Rett Syndrome Phenotypes.
Interplay between the E2F pathway and β-adrenergic signaling in the pathological hypertrophic response of myocardium.
Nummela P, Zafar S, Veikkolainen E, Ukkola I, Cinella V, Ayo A, Asghar MY, Välimäki N, Törnquist K, Karhu A, Laakkonen P, Aaltonen LA, Ristimäki A
International journal of cancer 2024 Jun 1;154(11):1987-1998
International journal of cancer 2024 Jun 1;154(11):1987-1998
Endoplasmic reticulum stress in pancreatic β cells induces incretin desensitization and β-cell dysfunction via ATF4-mediated PDE4D expression.
Lee JH, Ryu H, Lee H, Yu HR, Gao Y, Lee KM, Kim YJ, Lee J
American journal of physiology. Endocrinology and metabolism 2023 Nov 1;325(5):E448-E465
American journal of physiology. Endocrinology and metabolism 2023 Nov 1;325(5):E448-E465
An Artemisia scoparia extract attenuates glucocorticoid-induced lipolysis in adipocytes.
Harvey I, Stephens JM
Obesity (Silver Spring, Md.) 2023 Jul;31(7):1859-1870
Obesity (Silver Spring, Md.) 2023 Jul;31(7):1859-1870
Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth.
Jeong MH, Urquhart G, Lewis C, Chi Z, Jewell JL
JCI insight 2023 Jul 10;8(13)
JCI insight 2023 Jul 10;8(13)
PDE4D/cAMP/IL-23 axis determines the immunotherapy efficacy of lung adenocarcinoma via activating the IL-9 autocrine loop of cytotoxic T lymphocytes.
Feng B, Pan B, Huang J, Du Y, Wang X, Wu J, Ma R, Shen B, Huang G, Feng J
Cancer letters 2023 Jul 1;565:216224
Cancer letters 2023 Jul 1;565:216224
Synergistic effect of constituent drugs of Baibutang on improving Yin-deficiency pulmonary fibrosis in rats.
Fu S, Song X, Tang X, Qian X, Du Z, Hu Y, Xu X, Zhang M
Journal of ethnopharmacology 2023 Apr 24;306:116050
Journal of ethnopharmacology 2023 Apr 24;306:116050
Overexpression of PDE4D in mouse liver is sufficient to trigger NAFLD and hypertension in a CD36-TGF-β1 pathway: therapeutic role of roflumilast.
Tao X, He H, Peng J, Xu R, Fu J, Hu Y, Li L, Yang X, Feng X, Zhang C, Zhang L, Yu X, Shen A, Huang K, Fu Q
Pharmacological research 2022 Jan;175:106004
Pharmacological research 2022 Jan;175:106004
Targeting PDE4 as a promising therapeutic strategy in chronic ulcerative colitis through modulating mucosal homeostasis.
Li H, Zhang Y, Liu M, Fan C, Feng C, Lu Q, Xiang C, Lu H, Yang X, Wu B, Zou D, Tang W
Acta pharmaceutica Sinica. B 2022 Jan;12(1):228-245
Acta pharmaceutica Sinica. B 2022 Jan;12(1):228-245
FGF1 and insulin control lipolysis by convergent pathways.
Sancar G, Liu S, Gasser E, Alvarez JG, Moutos C, Kim K, van Zutphen T, Wang Y, Huddy TF, Ross B, Dai Y, Zepeda D, Collins B, Tilley E, Kolar MJ, Yu RT, Atkins AR, van Dijk TH, Saghatelian A, Jonker JW, Downes M, Evans RM
Cell metabolism 2022 Jan 4;34(1):171-183.e6
Cell metabolism 2022 Jan 4;34(1):171-183.e6
PDE4D binds and interacts with YAP to cooperatively promote HCC progression.
Ren H, Chen Y, Ao Z, Cheng Q, Yang X, Tao H, Zhao L, Shen A, Li P, Fu Q
Cancer letters 2022 Aug 10;541:215749
Cancer letters 2022 Aug 10;541:215749
MicroRNA-137-3p Improves Nonalcoholic Fatty Liver Disease through Activating AMPKα.
Yu Y, He C, Tan S, Huang M, Guo Y, Li M, Zhang Q
Analytical cellular pathology (Amsterdam) 2021;2021:4853355
Analytical cellular pathology (Amsterdam) 2021;2021:4853355
Evidence for reprogramming of monocytes into reparative alveolar macrophages in vivo by targeting PDE4b.
Rochford I, Joshi JC, Rayees S, Anwar M, Akhter MZ, Yalagala L, Banerjee S, Mehta D
American journal of physiology. Lung cellular and molecular physiology 2021 Oct 1;321(4):L686-L702
American journal of physiology. Lung cellular and molecular physiology 2021 Oct 1;321(4):L686-L702
Hyperinsulinemia promotes heterologous desensitization of β(2) adrenergic receptor in airway smooth muscle in obesity.
Xu R, Gopireddy RR, Wu Y, Wu L, Tao X, Shao J, Wang W, Li L, Jovanovic A, Xu B, Kenyon NJ, Lu Q, Xiang YK, Fu Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):3996-4008
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):3996-4008
Inhibition of PDE4/PDE4B improves renal function and ameliorates inflammation in cisplatin-induced acute kidney injury.
Xu M, Yu X, Meng X, Huang S, Zhang Y, Zhang A, Jia Z
American journal of physiology. Renal physiology 2020 Mar 1;318(3):F576-F588
American journal of physiology. Renal physiology 2020 Mar 1;318(3):F576-F588
Upregulation of miR-219a-5p Decreases Cerebral Ischemia/Reperfusion Injury In Vitro by Targeting Pde4d.
Lu MY, Wu JR, Liang RB, Wang YP, Zhu YC, Ma ZT, Zhang H, Zan J, Tan W
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2020 Jun;29(6):104801
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2020 Jun;29(6):104801
DC591017, a phosphodiesterase-4 (PDE4) inhibitor with robust anti-inflammation through regulating PKA-CREB signaling.
Li H, Li J, Zhang X, Feng C, Fan C, Yang X, Zhang R, Zhu F, Zhou Y, Xu Y, Liu H, Tang W
Biochemical pharmacology 2020 Jul;177:113958
Biochemical pharmacology 2020 Jul;177:113958
High expression of PDE4D correlates with poor prognosis and clinical progression in pancreaticductal adenocarcinoma.
Liu F, Ma J, Wang K, Li Z, Jiang Q, Chen H, Li W, Xia J
Journal of Cancer 2019;10(25):6252-6260
Journal of Cancer 2019;10(25):6252-6260
Inhibition of phosphodiesterase-4 attenuates murine ulcerative colitis through interference with mucosal immunity.
Li H, Fan C, Feng C, Wu Y, Lu H, He P, Yang X, Zhu F, Qi Q, Gao Y, Zuo J, Tang W
British journal of pharmacology 2019 Jul;176(13):2209-2226
British journal of pharmacology 2019 Jul;176(13):2209-2226
Molecular inotropy mediated by cardiac miR-based PDE4D/PRKAR1α/phosphoprotein signaling.
Bedada FB, Martindale JJ, Arden E, Metzger JM
Scientific reports 2016 Nov 11;6:36803
Scientific reports 2016 Nov 11;6:36803
Salt-Inducible Kinase 1 Terminates cAMP Signaling by an Evolutionarily Conserved Negative-Feedback Loop in β-Cells.
Kim MJ, Park SK, Lee JH, Jung CY, Sung DJ, Park JH, Yoon YS, Park J, Park KG, Song DK, Cho H, Kim ST, Koo SH
Diabetes 2015 Sep;64(9):3189-202
Diabetes 2015 Sep;64(9):3189-202
miR-199a Links MeCP2 with mTOR Signaling and Its Dysregulation Leads to Rett Syndrome Phenotypes.
Tsujimura K, Irie K, Nakashima H, Egashira Y, Fukao Y, Fujiwara M, Itoh M, Uesaka M, Imamura T, Nakahata Y, Yamashita Y, Abe T, Takamori S, Nakashima K
Cell reports 2015 Sep 22;12(11):1887-901
Cell reports 2015 Sep 22;12(11):1887-901
Interplay between the E2F pathway and β-adrenergic signaling in the pathological hypertrophic response of myocardium.
Major JL, Salih M, Tuana BS
Journal of molecular and cellular cardiology 2015 Jul;84:179-90
Journal of molecular and cellular cardiology 2015 Jul;84:179-90
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Supportive validation
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- Proteintech Group (provider)
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- Experimental details
- The PDE4D antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PDE4D. This antibody recognizes human,mouse,rat antigen. The PDE4D antibody has been validated for the following applications: ELISA, WB analysis.