PDE4D

This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins. [provided by RefSeq, Sep 2009]

Description

Phosphodiesterase 4D

Tissue specificity

Tissue enhanced (bone marrow, skeletal muscle)

Subcell location

Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Enzymes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

5 (58969038 - 60522120)

Ensembl ID

ENSG00000113448  (ver. 103.38)

Orthologs

Mouse Pde4d: ENSMUSG00000021699

UniProt

Q08499

neXtProt

NX_Q08499

Human splice variants
Mouse splice variants