VPREB1

The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Description

V-set pre-B cell surrogate light chain 1

Tissue specificity

Tissue enriched (bone marrow)

Predicted location

Intracellular

Protein family

CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

22 (22244780 - 22245515)

Ensembl ID

ENSG00000169575  (ver. 103.38)

Orthologs

-

UniProt

P12018

neXtProt

NX_P12018

Human splice variants

Protein structure