RUBCNL

This gene encodes a cysteine-rich protein that contains a putative zinc-RING and/or ribbon domain. The encoded protein is related to Run domain Beclin-1-interacting and cysteine-rich domain-containing protein, which plays a role in endocytic trafficking and autophagy. In cervical cancer cell lines, this gene is expressed at low levels and may function as a tumor suppressor. Promoter hypermethylation of this gene is observed in cervical cancer cell lines and tissue derived from human patients. [provided by RefSeq, Mar 2017]

Description

Rubicon like autophagy enhancer

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

13 (46334681 - 46438190)

Ensembl ID

ENSG00000102445  (ver. 103.38)

Orthologs

Mouse Rubcnl: ENSMUSG00000034959

UniProt

Q9H714

neXtProt

NX_Q9H714

Human splice variants
Mouse splice variants

Protein structure