NBP2-33159PEATT594

antibody from Novus Biologicals

Targeting: CD46 MCP, MGC26544, MIC10, TLX, TRA2.10

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

NBP2-33159PEATT594

Provider

Novus Biologicals

Product name

Mouse Monoclonal CD46 Antibody

Antibody type

Monoclonal

Description

Protein G purified. CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Reactivity

Human

Host

Mouse

Conjugate

Red dye

Isotype

IgG

Vial size

0.1 ml

Storage

Store at 4C in the dark. Do not freeze.