CD46

gene product
MCP, MGC26544, MIC10, TLX, TRA2.10
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
80 antibodies
Abgent
4 antibodies
antibodies-online
464 antibodies
Biorbyt
56 antibodies
NSJ Bioreagents
7 antibodies
OriGene
22 antibodies
Invitrogen Antibodies
16 antibodies
GeneTex
14 antibodies
Aviva Systems Biology
8 antibodies
Atlas Antibodies
1 antibody
NovoPro Bioscience Inc.
1 antibody
Proteintech Group
1 antibody
Acris Antibodies GmbH
21 antibodies
LifeSpan BioSciences, Inc.
191 antibodies