315302

antibody from BioLegend
Targeting: CD46 MCP, MGC26544, MIC10, TLX, TRA2.10
Provider product page for 315302
Western blot
Immunoprecipitation
Flow cytometry

Antibody data

Product number
315302 - Provider product page
Provider
BioLegend
Product name
Purified anti-human CD46
Antibody type
Monoclonal
Antigen
HPB-ALL T cell line
Description
CD46 is a transmembrane protein also known as complement membrane cofactor protein, MCP, and measles virus receptor. It is widely expressed on leukocytes, platelets, epithelial cells and fibroblasts. Multiple isoforms of CD46 have been reported with molecular weights ranging from 45-75 kD; CD46 binds complement components C3b and C4b and has also been reported to play a role in T cell regulation. In addition to the complement components, CD46 has been shown to interact with moesin, c-Src, tetraspanin 4, c-Yes, and integrin β1. CD46 is also known to be a cellular receptor for human measles virus and human herpes virus-6. Defects in CD46 have been associated with hemolytic-uremic syndrome. The MEM-258 antibody has been shown to be useful for flow cytometry, Western blotting, and immunoprecipitation.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Isotype
IgG
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
The antibody solution should be stored undiluted at 4°C.
CD46 protein structure - 315302 shown in red.