Tissue expression
Cell line expression
Protein structure
PSMC6
Proteasome 26S subunit, ATPase 6p42
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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LSBio | LS-C185613 | Polyclonal |
WB
ICC
IHC
|
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Proteintech Group | 15839-1-AP | 2 references | Polyclonal |
WB
EL
IHC
|
|
antibodies-online | ABIN393585 | Monoclonal |
WB
EL
ICC
IHC |
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Novus Biologicals | H00005706-M02 | Monoclonal |
WB
EL
ICC
BN |
||
Invitrogen Antibodies | 15839-1-AP | Polyclonal |
WB
ICC
IHC
|
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Supportive data in Antibodypedia
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Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider