DPABH-24930
antibody from Creative Diagnostics
Targeting: CD274
B7-H, B7-H1, B7H1, PD-L1, PDCD1LG1, PDL1
Antibody data
- Antibody Data
- Antigen structure
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- Product number
- DPABH-24930 - Provider product page
- Provider
- Creative Diagnostics
- Proper citation
- Creative Diagnostics Cat#DPABH-24930, RRID:AB_2518707
- Product name
- Rabbit Anti-Human CD274 Polyclonal antibody
- Antibody type
- Polyclonal
- Description
- PD-L1 (programmed cell death ligand 1, also known as CD274 or B7-H1) is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. PD-L1 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PD1-independent manner. PD-L1 is a 290 aa transmembrane protein with a calculated molecular weight of 33 kDa, it is predicted to be 27-30 kDa after signal peptide cleavage, as has been shown by several researches (PMID: 25609200
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