Tissue expression
Cell line expression
Protein structure

CD274

CD274 molecule
B7-H, B7-H1, B7H1, PD-L1, PDCD1LG1, PDL1 
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
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2903 antibodies from 57 providers.

Antibody properties

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
150 antibodies
Invitrogen Antibodies
260 antibodies
NSJ Bioreagents
25 antibodies
GeneTex
18 antibodies
R&D Systems
75 antibodies
Proteintech Group
10 antibodies
antibodies-online
311 antibodies
Cusabio Biotech Co., Ltd
5 antibodies
Cell Signaling Technology, Inc
17 antibodies
OriGene
130 antibodies
Biorbyt
535 antibodies
Acris Antibodies GmbH
25 antibodies
FineTest Biotech
2 antibodies
Everest Biotech
2 antibodies
Boster Biological Technology
10 antibodies
Arigo
2 antibodies
NovoPro Bioscience Inc.
18 antibodies
St John's Laboratory
46 antibodies
Abnova Corporation
17 antibodies
ABEOMICS Inc.
8 antibodies
ProSci
13 antibodies
Abgent
3 antibodies
Bethyl Laboratories
1 antibody
Aviva Systems Biology
14 antibodies
Antibodies.com
4 antibodies
Affinity Biosciences
1 antibody
Aladdin Scientific
19 antibodies
BioLegend
67 antibodies
Bioworld Technology, Inc
2 antibodies
PeproTech Inc.
6 antibodies
Creative Biolabs
515 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
HUABIO Research
1 antibody
MyBioSource
15 antibodies
MilliporeSigma / Merck KGaA
4 antibodies
Absolute Antibody
62 antibodies
Creative Diagnostics
29 antibodies
Abbexa
19 antibodies
Leading Biology
5 antibodies
Rockland Immunochemicals, Inc.
4 antibodies
Sino Biological Inc.
8 antibodies
Abbiotec
2 antibodies
EMD Millipore
6 antibodies
RayBiotech, Inc.
2 antibodies
Abiocode, Inc.
1 antibody
Exalpha Biologicals, Inc.
1 antibody
MS Validated Antibodies GmbH
1 antibody
QED Bioscience
1 antibody
United States Biological
57 antibodies
eBioscience, An Affymetrix Company
13 antibodies
Nordic BioSite
2 antibodies
ONCOdianova
1 antibody
MedChemExpress LLC
3 antibodies
CPTAC
1 antibody