Tissue expression
Cell line expression
Protein structure
CD274
CD274 moleculeB7-H, B7-H1, B7H1, PD-L1, PDCD1LG1, PDL1
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Top validated antibodies |
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Novus Biologicals | NBP1-76769 | 14 references | Polyclonal |
WB
EL
ICC
IP
IHC
FC |
|
Invitrogen Antibodies | PA5-20343 | 16 references | Polyclonal |
WB
ICC
IHC
FC
OA
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NSJ Bioreagents | V3955 | Monoclonal |
WB
ICC
IHC
FC
PA
OA |
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GeneTex | GTX31308 | 1 references | Polyclonal |
WB
EL
ICC
IHC
FC
|
|
Proteintech Group | 17952-1-AP | Polyclonal |
WB
EL
ICC
IP
IHC
FC |
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Supportive data in Antibodypedia
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Recommended by provider