CD274

gene product
B7-H, B7-H1, B7H1, PD-L1, PDCD1LG1, PDL1
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
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1765 antibodies from 47 providers.

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Novus Biologicals
150 antibodies
Proteintech Group
5 antibodies
NSJ Bioreagents
9 antibodies
GeneTex
18 antibodies
Invitrogen Antibodies
39 antibodies
R&D Systems
52 antibodies
antibodies-online
311 antibodies
Cell Signaling Technology, Inc
16 antibodies
OriGene
130 antibodies
Acris Antibodies GmbH
25 antibodies
Arigo
2 antibodies
NovoPro Bioscience Inc.
18 antibodies
Biorbyt
57 antibodies
LifeSpan BioSciences, Inc.
329 antibodies
Abnova Corporation
17 antibodies
Everest Biotech
1 antibody
ABEOMICS Inc.
8 antibodies
ProSci
13 antibodies
Abgent
3 antibodies
Rockland Immunochemicals, Inc.
4 antibodies
St John's Laboratory
10 antibodies
Aviva Systems Biology
14 antibodies
Antibodies.com
4 antibodies
Affinity Biosciences
1 antibody
BioLegend
67 antibodies
Bioworld Technology, Inc
2 antibodies
PeproTech Inc.
6 antibodies
Boster Biological Technology
5 antibodies
Creative Diagnostics
28 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Creative Biolabs
271 antibodies
MyBioSource
15 antibodies
Leading Biology
5 antibodies
Sino Biological Inc.
8 antibodies
Abbiotec
2 antibodies
EMD Millipore
6 antibodies
RayBiotech, Inc.
2 antibodies
Abbexa
1 antibody
Abiocode, Inc.
1 antibody
United States Biological
57 antibodies
Absolute Antibody
12 antibodies
eBioscience, An Affymetrix Company
13 antibodies
Sigma-Aldrich
3 antibodies
Nordic BioSite
2 antibodies
ONCOdianova
1 antibody
MedChemExpress LLC
3 antibodies