CABT-BL8451

antibody from Creative Diagnostics

Targeting: CD274 B7-H, B7-H1, B7H1, PD-L1, PDCD1LG1, PDL1

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

CABT-BL8451

Provider

Creative Diagnostics

Product name

Anti-PD-L1 monoclonal antibody, clone 9D7

Antibody type

Monoclonal

Description

Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that suppresses immune system. PD-L1 is expressed in hematopoietic and nonhematopoietic cells including T cells and B cells and various types of tumor cells. PD-L1 binds to its receptor Programmed death 1(PD1). During infection or inflammation, PD1- PD-L1 interaction is important for preventing autoimmunity. In tumor microenvironments, PD1-PD-L1 interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human cancers. In recent years, PDL1 has become an important biomarker and immunotherapy target for many types of malignancies.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

9D7

Vial size

50ul, 100ul

Storage

This antibody is shipped at 4°C. This product is stable for 12 months from date of receipt when stored at -20°C to -70°C. Avoid freeze/thaw cycles.