11-7543

antibody from ABEOMICS Inc.
Targeting: CD274 B7-H, B7-H1, B7H1, PD-L1, PDCD1LG1, PDL1
Provider product page for 11-7543

Antibody data

Product number
11-7543 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-PD-L1 Antibody
Antibody type
Polyclonal
Description
Programmed death ligand 1/PD-L1 (also called B7-H1 and CD274) is a T cell inhibitory molecule that is expressed on antigen presenting cells (APC) leading to T cell anergy and/or apoptosis upon ligation to its receptor Programmed death-1 (PD-1, CD279) on T cells. PD-L1 is expressed on tumor cells of a subset of breast cancer patients. It could also induce EMT and enhance RCC cell cancer stemness through up-regulation of SREBP-1c. Blocking the immunosuppressive PD-1/PD-L1 pathway has antitumor activity in multiple cancer types, and PD-L1 expression on tumor cells and infiltrating myeloid cells correlates with the likelihood of response.
Reactivity
Human
Host
Rabbit
Antigen sequence
A partial length recombinant PDL1 p
rotein (amino acids 18-227) was use
d as the immunogen for this antibod
y.
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
CD274 protein structure - 11-7543 shown in red.