Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 11-7543-25 - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-PD-L1 Antibody
- Antibody type
- Polyclonal
- Description
- Programmed death ligand 1/PD-L1 (also called B7-H1 and CD274) is a T cell inhibitory molecule that is expressed on antigen presenting cells (APC) leading to T cell anergy and/or apoptosis upon ligation to its receptor Programmed death-1 (PD-1, CD279) on T cells. PD-L1 is expressed on tumor cells of a subset of breast cancer patients. It could also induce EMT and enhance RCC cell cancer stemness through up-regulation of SREBP-1c. Blocking the immunosuppressive PD-1/PD-L1 pathway has antitumor activity in multiple cancer types, and PD-L1 expression on tumor cells and infiltrating myeloid cells correlates with the likelihood of response.
- Reactivity
- Human
- Host
- Rabbit
- Antigen sequence
A partial length recombinant PDL1 p
rotein (amino acids 18-227) was use
d as the immunogen for this antibod
y.- Vial size
- 25 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
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Supportive validation
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- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Expression analysis of PD-L1. Anti-PD-L1 antibody (11-7543) was used at 2 µg/ml on (1) Recombinant and (2) Raji lysates