Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 10-7562-F - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-Human PD-L1 Antibody
- Antibody type
- Monoclonal
- Description
- PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belongs to the B7 superfamily that inhibits immune responses through its receptor, PD-1 and PD-L1 play a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitate apoptosis of activated T cells and induce T cell anergy. Aberrant expression and dysregulation of CD274 have been reported during bacterial infection, inflammation and in numerous autoimmune diseases.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Green dye
- Antigen sequence
A partial length recombinant PDL1 p
rotein (amino acids 18-227) was use
d as the immunogen for this antibod
y.- Isotype
- IgG
- Antibody clone number
- ABM4E54
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
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Supportive validation
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Cell Surface FLOW analysis of PD-L1 FITC in PHA treated human PBMC using 1 µg of FITC conjugated PD-L1 antibody (Clone: ABM4E54). Green represents isotype control (ABEOMICS); red represents anti-PD-L1 (10-7562-F) antibody.
- Protocol
- Protocol